Advanced biosensing using simultaneous excitation of short and long range surface plasmons
Advanced biosensing using simultaneous excitation of short and long range surface plasmons
We present a novel optical biosensor which exploits simultaneous excitation of two different surface plasmons in a single sensing spot. It allows compensation of cross-sensitivity to background refractive index change, as a typical surface plasmon resonance sensor is sensitive to both the absorption of a thin film on the surface (sensing event) and the refractive index change of the background (an interfering effect). The structure parameters are optimized to yield low noise and minimum cross-sensitivity. In the performed model experiment, IgE biomolecules at a concentration of 250 ng ml-1 are detected during a change in the background refractive index of 10-3.
Biosensor, Optical sensor, Referencecompensated sensing, Surface plasmon resonance
932-938
Slavík, Radan
2591726a-ecc0-4d1a-8e1d-4d0fd8da8f7d
Homola, Jiří
9ae778bd-5e0d-4e3c-9597-17409470a575
Vaisocherová, Hana
bc20f77f-ee20-474d-b92e-4400246d91ed
1 April 2006
Slavík, Radan
2591726a-ecc0-4d1a-8e1d-4d0fd8da8f7d
Homola, Jiří
9ae778bd-5e0d-4e3c-9597-17409470a575
Vaisocherová, Hana
bc20f77f-ee20-474d-b92e-4400246d91ed
Slavík, Radan, Homola, Jiří and Vaisocherová, Hana
(2006)
Advanced biosensing using simultaneous excitation of short and long range surface plasmons.
Measurement Science and Technology, 17 (4), .
(doi:10.1088/0957-0233/17/4/045).
Abstract
We present a novel optical biosensor which exploits simultaneous excitation of two different surface plasmons in a single sensing spot. It allows compensation of cross-sensitivity to background refractive index change, as a typical surface plasmon resonance sensor is sensitive to both the absorption of a thin film on the surface (sensing event) and the refractive index change of the background (an interfering effect). The structure parameters are optimized to yield low noise and minimum cross-sensitivity. In the performed model experiment, IgE biomolecules at a concentration of 250 ng ml-1 are detected during a change in the background refractive index of 10-3.
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Published date: 1 April 2006
Keywords:
Biosensor, Optical sensor, Referencecompensated sensing, Surface plasmon resonance
Identifiers
Local EPrints ID: 456640
URI: http://eprints.soton.ac.uk/id/eprint/456640
ISSN: 0957-0233
PURE UUID: 3c0f1650-c125-4f38-8aff-af49289b53c4
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Date deposited: 05 May 2022 17:00
Last modified: 17 Mar 2024 03:16
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Contributors
Author:
Radan Slavík
Author:
Jiří Homola
Author:
Hana Vaisocherová
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