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Association of haptoglobin phenotype with neurological and cognitive outcomes in patients with subarachnoid hemorrhage

Association of haptoglobin phenotype with neurological and cognitive outcomes in patients with subarachnoid hemorrhage
Association of haptoglobin phenotype with neurological and cognitive outcomes in patients with subarachnoid hemorrhage
Background: To assess the association of haptoglobin (Hp) phenotype with neurological and cognitive outcomes in a large cohort of patients with subarachnoid hemorrhage (SAH). Methods: This prospective multicenter study enrolled patients with aneurysmal SAH between May 2015 and September 2020. The Hp phenotype was confirmed via Western blots. The relative intensities of α1 in individuals carrying Hp2-1 were compared with those of albumin. Multivariable logistic and Cox proportional-hazard regression analyses were used to identify the risk factors for 6-month and long-term outcomes, respectively. Results: A total of 336 patients including the phenotypes Hp1-1 (n = 31, 9.2%), Hp2-1 (n = 126, 37.5%), and Hp2-2 (n = 179, 53.3%) were analyzed. The Hp phenotype was closely associated with 6-month outcome (p = 0.001) and cognitive function (p = 0.013), and long-term outcome (p = 0.002) and cognitive function (p < 0.001). Compared with Hp1-1 as the reference value, Hp2-2 significantly increased the risk of 6-month poor outcome (OR: 7.868, 95% CI: 1.764-35.093) and cognitive impairment (OR: 8.056, 95% CI: 1.020-63.616), and long-term poor outcome (HR: 5.802, 95% CI: 1.795-18.754) and cognitive impairment (HR: 7.434, 95% CI: 2.264-24.409). Long-term cognitive impairment based on the Hp phenotype was significantly higher in patients under 65 years of age (p < 0.001) and female gender (p < 0.001). A lower relative α1/albumin intensity (OR: 0.010, 95% CI: 0.000-0.522) was associated with poor outcome at 6 months but not cognitive impairment in patients with SAH expressing Hp2-1. Conclusion: Hp2-2 increased the risk of poor neurological outcomes and cognitive impairment compared with Hp1-1. For Hp2-1, higher relative α1 intensities were related to 6-month favorable outcomes. Keywords: cognition; haptoglobin; intracranial aneurysm; outcome; subarachnoid hemorrhage. Copyright © 2022 Han, Kim, Kim, Lim, Youn, Hong, Rhim, Park, Lee, Cho, Gaastra, Galea and Jeon.
cognition, haptoglobin, intracranial aneurysm, outcome, subarachnoid hemorrhage
1663-4365
Han, Sung Woo
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Kim, Bong Jun
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Kim, Tae Yeon
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Lim, Seung Hyuk
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Youn, Dong Hyuk
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Hong, Eun Pyo
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Rhim, Jong Kook
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Park, Jeong Jin
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Lee, Jae Jun
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Cho, Yong Jun
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Gaastra, Ben
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Galea, Ian
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Jeon, Jin Pyeong
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Han, Sung Woo
17869651-6f47-4fea-83fd-6a1b9a43bf53
Kim, Bong Jun
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Kim, Tae Yeon
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Lim, Seung Hyuk
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Youn, Dong Hyuk
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Hong, Eun Pyo
be02f781-7328-4061-97e7-ce54e3215369
Rhim, Jong Kook
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Park, Jeong Jin
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Lee, Jae Jun
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Cho, Yong Jun
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Gaastra, Ben
c7b7f371-706b-4d59-9150-94e8f254e205
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Jeon, Jin Pyeong
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Han, Sung Woo, Kim, Bong Jun, Kim, Tae Yeon, Lim, Seung Hyuk, Youn, Dong Hyuk, Hong, Eun Pyo, Rhim, Jong Kook, Park, Jeong Jin, Lee, Jae Jun, Cho, Yong Jun, Gaastra, Ben, Galea, Ian and Jeon, Jin Pyeong (2022) Association of haptoglobin phenotype with neurological and cognitive outcomes in patients with subarachnoid hemorrhage. Frontiers in Aging Neuroscience, 14, [819628]. (doi:10.3389/fnagi.2022.819628).

Record type: Article

Abstract

Background: To assess the association of haptoglobin (Hp) phenotype with neurological and cognitive outcomes in a large cohort of patients with subarachnoid hemorrhage (SAH). Methods: This prospective multicenter study enrolled patients with aneurysmal SAH between May 2015 and September 2020. The Hp phenotype was confirmed via Western blots. The relative intensities of α1 in individuals carrying Hp2-1 were compared with those of albumin. Multivariable logistic and Cox proportional-hazard regression analyses were used to identify the risk factors for 6-month and long-term outcomes, respectively. Results: A total of 336 patients including the phenotypes Hp1-1 (n = 31, 9.2%), Hp2-1 (n = 126, 37.5%), and Hp2-2 (n = 179, 53.3%) were analyzed. The Hp phenotype was closely associated with 6-month outcome (p = 0.001) and cognitive function (p = 0.013), and long-term outcome (p = 0.002) and cognitive function (p < 0.001). Compared with Hp1-1 as the reference value, Hp2-2 significantly increased the risk of 6-month poor outcome (OR: 7.868, 95% CI: 1.764-35.093) and cognitive impairment (OR: 8.056, 95% CI: 1.020-63.616), and long-term poor outcome (HR: 5.802, 95% CI: 1.795-18.754) and cognitive impairment (HR: 7.434, 95% CI: 2.264-24.409). Long-term cognitive impairment based on the Hp phenotype was significantly higher in patients under 65 years of age (p < 0.001) and female gender (p < 0.001). A lower relative α1/albumin intensity (OR: 0.010, 95% CI: 0.000-0.522) was associated with poor outcome at 6 months but not cognitive impairment in patients with SAH expressing Hp2-1. Conclusion: Hp2-2 increased the risk of poor neurological outcomes and cognitive impairment compared with Hp1-1. For Hp2-1, higher relative α1 intensities were related to 6-month favorable outcomes. Keywords: cognition; haptoglobin; intracranial aneurysm; outcome; subarachnoid hemorrhage. Copyright © 2022 Han, Kim, Kim, Lim, Youn, Hong, Rhim, Park, Lee, Cho, Gaastra, Galea and Jeon.

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Published date: 21 March 2022
Additional Information: Funding Information: This research was supported by the National Research Foundation of Korea funded by the Ministry of Education (2020R1l1A3070726), the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare of South Korea (grant number: HR21C0198), and Hallym University Research fund. Publisher Copyright: Copyright © 2022 Han, Kim, Kim, Lim, Youn, Hong, Rhim, Park, Lee, Cho, Gaastra, Galea and Jeon.
Keywords: cognition, haptoglobin, intracranial aneurysm, outcome, subarachnoid hemorrhage

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Local EPrints ID: 456684
URI: http://eprints.soton.ac.uk/id/eprint/456684
ISSN: 1663-4365
PURE UUID: 129962ee-87e8-4f3d-8459-eaa2d99a7f5d
ORCID for Ben Gaastra: ORCID iD orcid.org/0000-0002-7517-6882
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

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Date deposited: 06 May 2022 16:52
Last modified: 17 Mar 2024 04:07

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Contributors

Author: Sung Woo Han
Author: Bong Jun Kim
Author: Tae Yeon Kim
Author: Seung Hyuk Lim
Author: Dong Hyuk Youn
Author: Eun Pyo Hong
Author: Jong Kook Rhim
Author: Jeong Jin Park
Author: Jae Jun Lee
Author: Yong Jun Cho
Author: Ben Gaastra ORCID iD
Author: Ian Galea ORCID iD
Author: Jin Pyeong Jeon

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