Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Accepted/In Press date: 1 April 2022

e-pub ahead of print date: 23 April 2022

Published date: August 2022

Additional Information: Funding Information: This study would not be possible without all the participants who have given their time and support. We thank all the participants and their families. We thank the many research administrators and health-care and social-care professionals who contributed to setting up and delivering the study at all of the 69 NHS trusts and 25 research institutions across the UK, as well as all the supporting staff at the NIHR Clinical Research Network, Health Research Authority, Research Ethics Committee, Department of Health and Social Care Public Health Scotland, Public Health England, and support from the ISARIC Coronavirus Clinical Characterisation Consortium. At the NIHR Office for Clinical Research Infrastructure, we thank Kate Holmes for her support in coordinating the charities group. We are very grateful to all the charities that have provided insight to the study—Action Pulmonary Fibrosis, Alzheimer's Research UK, Asthma UK, British Lung Foundation UK, British Heart Foundation, Diabetes UK, Cystic Fibrosis Trust, Kidney Research UK, MQ Mental Health, Muscular Dystrophy UK, Stroke Association Blood Cancer UK, McPin Foundations, and Versus Arthritis. We thank the NIHR Leicester Biomedical Research Centre patient and public involvement group and the Long Covid Support Group. This research used the SPECTRE High Performance Computing Facility at the University of Leicester, Leicester, UK. PHOSP-COVID is supported by a grant from MRC Research and Innovation and the Department of Health and Social Care through the NIHR rapid response panel to tackle COVID-19 (MR/V027859/1 and COV0319). Core funding was provided by NIHR Leicester Biomedical Research Centre to support the PHOSP-COVID coordination team and NIHR biomedical research centres, clinical research facilities, NIHR health protection research unit, and translational research collaborations network across the country. The institutional funding that supports the outbreak labs that process the PHOSP samples are from the NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK, in partnership with Public Health England and Liverpool Experimental Cancer Medicine Centre (C18616/A25153). ABD is funded by a Wellcome Trust grant (216606/Z/19/Z); RAE holds an NIHR clinician scientist fellowship (CS-2016-16-020); NJG holds an NIHR post-doctoral fellowship (PDF-2017-10-052); JJ was supported by a Wellcome Trust Clinical Research Career Development Fellowship (209553/Z/17/Z) and by the NIHR University College London Hospital Biomedical Research Centre, UK; LVW was supported by a GlaxoSmithKline and British Lung Foundation chair in respiratory research (C17-1); and DGW is supported by an NIHR advanced fellowship (NIHR300669). The views expressed in this publication are those of the author(s) and not necessarily those of the MRC, NIHR, or the UK Department of Health and Social Care. No form of payment was given to anyone to produce the manuscript. Funding Information: This study would not be possible without all the participants who have given their time and support. We thank all the participants and their families. We thank the many research administrators and health-care and social-care professionals who contributed to setting up and delivering the study at all of the 69 NHS trusts and 25 research institutions across the UK, as well as all the supporting staff at the NIHR Clinical Research Network, Health Research Authority, Research Ethics Committee, Department of Health and Social Care Public Health Scotland, Public Health England, and support from the ISARIC Coronavirus Clinical Characterisation Consortium. At the NIHR Office for Clinical Research Infrastructure, we thank Kate Holmes for her support in coordinating the charities group. We are very grateful to all the charities that have provided insight to the study—Action Pulmonary Fibrosis, Alzheimer's Research UK, Asthma UK, British Lung Foundation UK, British Heart Foundation, Diabetes UK, Cystic Fibrosis Trust, Kidney Research UK, MQ Mental Health, Muscular Dystrophy UK, Stroke Association Blood Cancer UK, McPin Foundations, and Versus Arthritis. We thank the NIHR Leicester Biomedical Research Centre patient and public involvement group and the Long Covid Support Group. This research used the SPECTRE High Performance Computing Facility at the University of Leicester, Leicester, UK. PHOSP-COVID is supported by a grant from MRC Research and Innovation and the Department of Health and Social Care through the NIHR rapid response panel to tackle COVID-19 (MR/V027859/1 and COV0319). Core funding was provided by NIHR Leicester Biomedical Research Centre to support the PHOSP-COVID coordination team and NIHR biomedical research centres, clinical research facilities, NIHR health protection research unit, and translational research collaborations network across the country. The institutional funding that supports the outbreak labs that process the PHOSP samples are from the NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK, in partnership with Public Health England and Liverpool Experimental Cancer Medicine Centre (C18616/A25153). ABD is funded by a Wellcome Trust grant (216606/Z/19/Z); RAE holds an NIHR clinician scientist fellowship (CS-2016-16-020); NJG holds an NIHR post-doctoral fellowship (PDF-2017-10-052); JJ was supported by a Wellcome Trust Clinical Research Career Development Fellowship (209553/Z/17/Z) and by the NIHR University College London Hospital Biomedical Research Centre, UK; LVW was supported by a GlaxoSmithKline and British Lung Foundation chair in respiratory research (C17-1); and DGW is supported by an NIHR advanced fellowship (NIHR300669). The views expressed in this publication are those of the author(s) and not necessarily those of the MRC, NIHR, or the UK Department of Health and Social Care. No form of payment was given to anyone to produce the manuscript. Publisher Copyright: © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Local EPrints ID: 456711

URI: http://eprints.soton.ac.uk/id/eprint/456711

DOI: doi:10.1016/S2213-2600(22)00127-8

ISSN: 2213-2600

PURE UUID: cc148938-1d76-4434-9115-d3c178be1ce4

ORCID for Mark Jones: orcid.org/0000-0001-6308-6014

ORCID for Philip Calder: orcid.org/0000-0002-6038-710X

Date deposited: 09 May 2022 17:21

Last modified: 17 Mar 2024 03:12