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Microfluidic technologies for ex vivo tissue biopsies: a review

Microfluidic technologies for ex vivo tissue biopsies: a review
Microfluidic technologies for ex vivo tissue biopsies: a review
Traditional in vitro models and animal models often lack the physiological complexity or the accuracy to obtain predictive responses that are clinically translatable to humans. With the advent of microphysiological systems over recent years, new models that are able to mimic human biology more closely have been developed. The culture of whole tissue samples within microfluidic devices promises to bridge preclinical and clinical research, and has the potential to be applied in personalised medicine, environmental sciences or the food industry. However, many challenges must be addressed in terms of tissue maintenance ex vivo or methods for analysing samples, particularly in real-time. In this review, we explore the microfluidic strategies that have been reported for the culture of tissue biopsies ex vivo and the different techniques that have been explored in order to expand their life span, control the microenvironment and interrogate the samples. Current challenges facing the field are discussed.
Keywords: Microfluidics
Garcia Garcia, Fernando, Carlos
e140af60-c7a2-463e-b114-9fcd72342752
Candarlioglu, Pelin
aad84455-7dc5-4c4d-a226-172313da971c
Porter, James
127bad47-d8f8-45b6-801c-4fde07e2ce40
Swindle, Emily
fe393c7a-a513-4de4-b02e-27369bd7e84f
Davies, Donna
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Garcia Garcia, Fernando, Carlos
e140af60-c7a2-463e-b114-9fcd72342752
Candarlioglu, Pelin
aad84455-7dc5-4c4d-a226-172313da971c
Porter, James
127bad47-d8f8-45b6-801c-4fde07e2ce40
Swindle, Emily
fe393c7a-a513-4de4-b02e-27369bd7e84f
Davies, Donna
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174

Garcia Garcia, Fernando, Carlos, Candarlioglu, Pelin, Porter, James, Swindle, Emily, Davies, Donna and Morgan, Hywel (2022) Microfluidic technologies for ex vivo tissue biopsies: a review. Organs-on-a-Chip. (doi:10.1016/j.ooc.2022.100020). (In Press)

Record type: Review

Abstract

Traditional in vitro models and animal models often lack the physiological complexity or the accuracy to obtain predictive responses that are clinically translatable to humans. With the advent of microphysiological systems over recent years, new models that are able to mimic human biology more closely have been developed. The culture of whole tissue samples within microfluidic devices promises to bridge preclinical and clinical research, and has the potential to be applied in personalised medicine, environmental sciences or the food industry. However, many challenges must be addressed in terms of tissue maintenance ex vivo or methods for analysing samples, particularly in real-time. In this review, we explore the microfluidic strategies that have been reported for the culture of tissue biopsies ex vivo and the different techniques that have been explored in order to expand their life span, control the microenvironment and interrogate the samples. Current challenges facing the field are discussed.
Keywords: Microfluidics

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Accepted/In Press date: 6 April 2022

Identifiers

Local EPrints ID: 456762
URI: http://eprints.soton.ac.uk/id/eprint/456762
PURE UUID: 8ee9d204-4143-40eb-9550-5e564de9a439
ORCID for Fernando, Carlos Garcia Garcia: ORCID iD orcid.org/0000-0003-0539-5884
ORCID for Emily Swindle: ORCID iD orcid.org/0000-0003-3644-7747
ORCID for Donna Davies: ORCID iD orcid.org/0000-0002-5117-2991
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676

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Date deposited: 10 May 2022 17:06
Last modified: 17 Mar 2024 03:54

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Contributors

Author: Fernando, Carlos Garcia Garcia ORCID iD
Author: Pelin Candarlioglu
Author: James Porter
Author: Emily Swindle ORCID iD
Author: Donna Davies ORCID iD
Author: Hywel Morgan ORCID iD

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