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Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection
Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NHC were significantly correlated with plasma (P<.0001). Clinical Trials Registration. NCT04746183.

COVID-19, SARS-CoV-2, molnupiravir, nonplasma, pharmacokinetics
1058-4838
E525-E528
FitzGerald, Richard
c633872f-cab4-4b44-886a-704b40d84f38
Dickinson, Laura
2de19256-6a07-4497-81d7-aba38e9420ef
Else, Laura
2273db71-d4f5-4cc2-9ba9-619e51657209
Fletcher, Thomas
840fd092-4846-4382-bafb-10f59ced0664
Hale, Colin
da2d7af1-b721-4cc6-806d-d2cd9d995336
Amara, Alieu
f09fade0-a4a0-4b94-a71c-40c42e3bae05
Walker, Lauren
b68adbc8-08f1-447b-a26b-6be2f601cf0f
Penchala, Sujan Dilly
51a4f82f-ff3a-4af2-8bd3-6a7413a87755
Lyon, Rebecca
3f581846-7f3f-436c-9be1-86b77d4d362b
Shaw, Victoria
491a53a2-8358-4124-b86a-46a55858e669
Greenhalf, William
8a259791-6f89-4ebf-84bf-a81ea681e347
Bullock, Katie
2aec910a-a05e-46a3-9c36-800f77987c98
Lavelle-Langham, Lara
a533d33b-858a-43bd-8235-d6149f58c2f2
Reynolds, Helen
b39593c5-bf19-4cf9-aac4-b439c2ea7543
Painter, Wendy
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Holman, Wayne
a39b08ce-1745-415f-b159-f0a8d47bcbf6
Ewings, Sean
e8438e8d-8b0c-4813-8fa9-39e3de5c98d8
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Khoo, Saye
4ad67fee-e6a4-43d2-b7a8-5920d718f568
FitzGerald, Richard
c633872f-cab4-4b44-886a-704b40d84f38
Dickinson, Laura
2de19256-6a07-4497-81d7-aba38e9420ef
Else, Laura
2273db71-d4f5-4cc2-9ba9-619e51657209
Fletcher, Thomas
840fd092-4846-4382-bafb-10f59ced0664
Hale, Colin
da2d7af1-b721-4cc6-806d-d2cd9d995336
Amara, Alieu
f09fade0-a4a0-4b94-a71c-40c42e3bae05
Walker, Lauren
b68adbc8-08f1-447b-a26b-6be2f601cf0f
Penchala, Sujan Dilly
51a4f82f-ff3a-4af2-8bd3-6a7413a87755
Lyon, Rebecca
3f581846-7f3f-436c-9be1-86b77d4d362b
Shaw, Victoria
491a53a2-8358-4124-b86a-46a55858e669
Greenhalf, William
8a259791-6f89-4ebf-84bf-a81ea681e347
Bullock, Katie
2aec910a-a05e-46a3-9c36-800f77987c98
Lavelle-Langham, Lara
a533d33b-858a-43bd-8235-d6149f58c2f2
Reynolds, Helen
b39593c5-bf19-4cf9-aac4-b439c2ea7543
Painter, Wendy
e2d1ba45-e722-4c9f-8524-8f1abbcde313
Holman, Wayne
a39b08ce-1745-415f-b159-f0a8d47bcbf6
Ewings, Sean
e8438e8d-8b0c-4813-8fa9-39e3de5c98d8
Griffiths, Gareth
7fd300c0-d279-4ff6-842d-aa1f2b9b864d
Khoo, Saye
4ad67fee-e6a4-43d2-b7a8-5920d718f568

FitzGerald, Richard, Dickinson, Laura, Else, Laura, Fletcher, Thomas, Hale, Colin, Amara, Alieu, Walker, Lauren, Penchala, Sujan Dilly, Lyon, Rebecca, Shaw, Victoria, Greenhalf, William, Bullock, Katie, Lavelle-Langham, Lara, Reynolds, Helen, Painter, Wendy, Holman, Wayne, Ewings, Sean, Griffiths, Gareth and Khoo, Saye (2022) Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection. Clinical Infectious Diseases, 75 (1), E525-E528. (doi:10.1093/cid/ciac199).

Record type: Article

Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at SARS-CoV-2 transmission sites in 12 patients enrolled in AGILE Candidate-Specific Trial-2. Saliva, nasal, and tear NHC concentrations were 3%, 21%, and 22% that of plasma. Saliva and nasal NHC were significantly correlated with plasma (P<.0001). Clinical Trials Registration. NCT04746183.

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e-pub ahead of print date: 10 March 2022
Published date: 24 August 2022
Keywords: COVID-19, SARS-CoV-2, molnupiravir, nonplasma, pharmacokinetics

Identifiers

Local EPrints ID: 456824
URI: http://eprints.soton.ac.uk/id/eprint/456824
DOI: doi:10.1093/cid/ciac199
ISSN: 1058-4838
PURE UUID: b50006f4-b1db-456f-8cfb-fbb8e84bbb73
ORCID for Gareth Griffiths: ORCID iD orcid.org/0000-0002-9579-8021

Catalogue record

Date deposited: 12 May 2022 16:38
Last modified: 17 Mar 2024 03:36

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Contributors

Author: Richard FitzGerald
Author: Laura Dickinson
Author: Laura Else
Author: Thomas Fletcher
Author: Colin Hale
Author: Alieu Amara
Author: Lauren Walker
Author: Sujan Dilly Penchala
Author: Rebecca Lyon
Author: Victoria Shaw
Author: William Greenhalf
Author: Katie Bullock
Author: Lara Lavelle-Langham
Author: Helen Reynolds
Author: Wendy Painter
Author: Wayne Holman
Author: Sean Ewings
Author: Gareth Griffiths ORCID iD
Author: Saye Khoo

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