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Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection
Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

1058-4838
FitzGerald, Richard
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Dickinson, Laura
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Else, Laura
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Fletcher, Thomas
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Hale, Colin
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Amara, Alieu
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Walker, Lauren
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Penchala, Sujan Dilly
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Lyon, Rebecca
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Shaw, Victoria
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Greenhalf, William
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Bullock, Katie
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Lavelle-Langham, Lara
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Reynolds, Helen
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Painter, Wendy
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Holman, Wayne
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Ewings, Sean
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Griffiths, Gareth
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Khoo, Saye
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FitzGerald, Richard
c633872f-cab4-4b44-886a-704b40d84f38
Dickinson, Laura
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Else, Laura
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Fletcher, Thomas
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Hale, Colin
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Amara, Alieu
f09fade0-a4a0-4b94-a71c-40c42e3bae05
Walker, Lauren
b68adbc8-08f1-447b-a26b-6be2f601cf0f
Penchala, Sujan Dilly
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Lyon, Rebecca
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Shaw, Victoria
491a53a2-8358-4124-b86a-46a55858e669
Greenhalf, William
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Bullock, Katie
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Lavelle-Langham, Lara
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Reynolds, Helen
b39593c5-bf19-4cf9-aac4-b439c2ea7543
Painter, Wendy
e2d1ba45-e722-4c9f-8524-8f1abbcde313
Holman, Wayne
a39b08ce-1745-415f-b159-f0a8d47bcbf6
Ewings, Sean
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Griffiths, Gareth
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Khoo, Saye
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FitzGerald, Richard, Dickinson, Laura, Else, Laura, Fletcher, Thomas, Hale, Colin, Amara, Alieu, Walker, Lauren, Penchala, Sujan Dilly, Lyon, Rebecca, Shaw, Victoria, Greenhalf, William, Bullock, Katie, Lavelle-Langham, Lara, Reynolds, Helen, Painter, Wendy, Holman, Wayne, Ewings, Sean, Griffiths, Gareth and Khoo, Saye (2022) Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection. Clinical Infectious Diseases. (doi:10.1093/cid/ciac199).

Record type: Article

Abstract

ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at sites of SARS-CoV-2 transmission in twelve patients enrolled in AGILE CST-2 (NCT04746183). Saliva, nasal and tear concentrations were 3, 21 and 22% that of plasma. Saliva and nasal NHC concentrations were significantly correlated with plasma (p<0.0001).

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e-pub ahead of print date: 10 March 2022

Identifiers

Local EPrints ID: 456824
URI: http://eprints.soton.ac.uk/id/eprint/456824
ISSN: 1058-4838
PURE UUID: b50006f4-b1db-456f-8cfb-fbb8e84bbb73
ORCID for Gareth Griffiths: ORCID iD orcid.org/0000-0002-9579-8021

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Date deposited: 12 May 2022 16:38
Last modified: 19 Jul 2022 01:51

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Contributors

Author: Richard FitzGerald
Author: Laura Dickinson
Author: Laura Else
Author: Thomas Fletcher
Author: Colin Hale
Author: Alieu Amara
Author: Lauren Walker
Author: Sujan Dilly Penchala
Author: Rebecca Lyon
Author: Victoria Shaw
Author: William Greenhalf
Author: Katie Bullock
Author: Lara Lavelle-Langham
Author: Helen Reynolds
Author: Wendy Painter
Author: Wayne Holman
Author: Sean Ewings
Author: Saye Khoo

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