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The mediating pathways between parental separation in childhood and offspring hypertension at midlife

The mediating pathways between parental separation in childhood and offspring hypertension at midlife
The mediating pathways between parental separation in childhood and offspring hypertension at midlife
Social life course determinants of adult hypertension are relatively unknown. This paper examines how parental separation before age 10 relates to hypertension at age 46. Adjusting for parental confounders and considering the role of adult mediators, we aim to quantify unexplored mediating pathways in childhood using prospectively collected data. Data from the 1970 British Birth Cohort Study are utilised. Hypertension is measured by health care professionals at age 46. Potential mediating pathways in childhood include body mass index (BMI), systolic and diastolic blood pressure, illness, disability, family socioeconomic status (SES) and cognitive and developmental indicators at age 10. Additionally, we explore to what extent childhood mediators operate through adult mediators, including health behaviours, family SES, BMI and mental wellbeing. We also test for effect modification of the relationship between parental separation and hypertension by gender. Nested logistic regression models test the significance of potential mediating variables. Formal mediation analysis utilising Karlson Holm and Breen (KHB) method quantify the direct and indirect effect of parental separation on offspring hypertension at midlife. There was an association between parental separation and hypertension in mid-life in women but not men. For women, family SES and cognitive and behavioural development indicators at age 10 partly mediate the relationship between parental separation and hypertension at age 46. When adult mediators including, health behaviours, family SES, BMI and mental wellbeing are included, the associations between the childhood predictors and adult hypertension are attenuated, suggesting that these childhood mediators in turn may work through adult mediators to affect the risk of hypertension in midlife. We found family SES in childhood, cognitive and behaviour development indicators at age 10, including disruptive behaviour, coordination and locus of control in childhood, to be important mediators of the relationship between parental separation and midlife hypertension suggesting that intervening in childhood may modify adult hypertension risk.
2045-2322
Stannard, Sebastian
99ffc90e-bf03-4cd4-9e63-a023491b1d36
Berrington, Ann
bd0fc093-310d-4236-8126-ca0c7eb9ddde
Alwan, Nisreen
0d37b320-f325-4ed3-ba51-0fe2866d5382
Stannard, Sebastian
99ffc90e-bf03-4cd4-9e63-a023491b1d36
Berrington, Ann
bd0fc093-310d-4236-8126-ca0c7eb9ddde
Alwan, Nisreen
0d37b320-f325-4ed3-ba51-0fe2866d5382

Stannard, Sebastian, Berrington, Ann and Alwan, Nisreen (2022) The mediating pathways between parental separation in childhood and offspring hypertension at midlife. Scientific Reports, 12 (1), [7062]. (doi:10.1038/s41598-022-11007-z).

Record type: Article

Abstract

Social life course determinants of adult hypertension are relatively unknown. This paper examines how parental separation before age 10 relates to hypertension at age 46. Adjusting for parental confounders and considering the role of adult mediators, we aim to quantify unexplored mediating pathways in childhood using prospectively collected data. Data from the 1970 British Birth Cohort Study are utilised. Hypertension is measured by health care professionals at age 46. Potential mediating pathways in childhood include body mass index (BMI), systolic and diastolic blood pressure, illness, disability, family socioeconomic status (SES) and cognitive and developmental indicators at age 10. Additionally, we explore to what extent childhood mediators operate through adult mediators, including health behaviours, family SES, BMI and mental wellbeing. We also test for effect modification of the relationship between parental separation and hypertension by gender. Nested logistic regression models test the significance of potential mediating variables. Formal mediation analysis utilising Karlson Holm and Breen (KHB) method quantify the direct and indirect effect of parental separation on offspring hypertension at midlife. There was an association between parental separation and hypertension in mid-life in women but not men. For women, family SES and cognitive and behavioural development indicators at age 10 partly mediate the relationship between parental separation and hypertension at age 46. When adult mediators including, health behaviours, family SES, BMI and mental wellbeing are included, the associations between the childhood predictors and adult hypertension are attenuated, suggesting that these childhood mediators in turn may work through adult mediators to affect the risk of hypertension in midlife. We found family SES in childhood, cognitive and behaviour development indicators at age 10, including disruptive behaviour, coordination and locus of control in childhood, to be important mediators of the relationship between parental separation and midlife hypertension suggesting that intervening in childhood may modify adult hypertension risk.

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Accepted/In Press date: 15 April 2022
Published date: 29 April 2022
Additional Information: Funding Information: This work was funded by the Economic and Social Research Council (UK) [ES/P000673/1], and supported by ESRC Centre for Population Change (UK). Publisher Copyright: © 2022, The Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.

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Local EPrints ID: 456957
URI: http://eprints.soton.ac.uk/id/eprint/456957
ISSN: 2045-2322
PURE UUID: 13c3f44e-8f47-4274-bc1b-2ae190a33337
ORCID for Ann Berrington: ORCID iD orcid.org/0000-0002-1683-6668
ORCID for Nisreen Alwan: ORCID iD orcid.org/0000-0002-4134-8463

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Date deposited: 18 May 2022 16:48
Last modified: 25 May 2022 01:44

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Contributors

Author: Sebastian Stannard
Author: Ann Berrington ORCID iD
Author: Nisreen Alwan ORCID iD

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