Elevated plasma matrix metalloproteinase-8 associates with sputum culture positivity in pulmonary tuberculosis
Elevated plasma matrix metalloproteinase-8 associates with sputum culture positivity in pulmonary tuberculosis
Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.
HIV, Tuberculosis, diagnosis, immunopathology, matrix metalloproteinase, procollagen III N-terminal propeptide
928-932
Walker, NF
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Karim, F
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Moosa, MY
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Moodley, S
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Mazibuko, M
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Khan, K
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Sterling, TR
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van der Heijden, YF
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Grant, AD
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Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Pym, A
0715fc48-af68-477b-9c1f-ed6b51d4bf5f
Leslie, A
9521da48-518e-40c1-890c-0cd8e20f9494
13 September 2022
Walker, NF
e586ffdf-ae4b-46fa-83a1-db72501d17c1
Karim, F
5f47c4e2-5e49-4c6d-84bd-ba1f844ff8db
Moosa, MY
592c5c37-7cbf-492b-8b08-09c98ccc6722
Moodley, S
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Mazibuko, M
6cc55990-5635-4f2e-93bd-1d1eae8f8d9a
Khan, K
5192320a-e791-4cfe-b4b9-2e604e5617ec
Sterling, TR
6e418c68-68f6-48d2-a3c4-6663d25fc906
van der Heijden, YF
fd88a1dd-178e-4f84-a2f2-18395829a52f
Grant, AD
bfd4d62c-1239-4d1b-aad6-83445ff7c950
Elkington, Paul
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Pym, A
0715fc48-af68-477b-9c1f-ed6b51d4bf5f
Leslie, A
9521da48-518e-40c1-890c-0cd8e20f9494
Walker, NF, Karim, F, Moosa, MY, Moodley, S, Mazibuko, M, Khan, K, Sterling, TR, van der Heijden, YF, Grant, AD, Elkington, Paul, Pym, A and Leslie, A
(2022)
Elevated plasma matrix metalloproteinase-8 associates with sputum culture positivity in pulmonary tuberculosis.
The Journal of Infectious Diseases, 226 (5), , [jiac160].
(doi:10.1093/infdis/jiac160).
Abstract
Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.
Text
CUBS_MMP_v1.4_accepted
More information
Accepted/In Press date: 25 April 2022
Published date: 13 September 2022
Additional Information:
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Keywords:
HIV, Tuberculosis, diagnosis, immunopathology, matrix metalloproteinase, procollagen III N-terminal propeptide
Identifiers
Local EPrints ID: 456987
URI: http://eprints.soton.ac.uk/id/eprint/456987
ISSN: 0022-1899
PURE UUID: 7789dad9-056a-46a2-99c4-1ae3349e6847
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Date deposited: 19 May 2022 16:31
Last modified: 17 Mar 2024 07:16
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Contributors
Author:
NF Walker
Author:
F Karim
Author:
MY Moosa
Author:
S Moodley
Author:
M Mazibuko
Author:
K Khan
Author:
TR Sterling
Author:
YF van der Heijden
Author:
AD Grant
Author:
A Pym
Author:
A Leslie
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