Kothalawala, Dilini M., Weiss, Veronique B. N., Kadalayil, Latha, Granell, Raquel, Curtin, John A., Murray, Clare S., Simpson, Angela, Custovic, Adnan, Tapper, William J., Rezwan, Faisal I., Arshad, Syed Hasan and Holloway, John W. (2022) Nonlinear effects of environment on childhood asthma susceptibility. Pediatric Allergy and Immunology, 33 (4), e13777, [e13777]. (doi:10.1111/pai.13777).
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Pediatric Allergy Immunology - 2022 - Kothalawala - Nonlinear effects of environment on childhood asthma susceptibility[63]
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Pediatric Allergy Immunology - 2022 - Kothalawala - Nonlinear effects of environment on childhood asthma susceptibility
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Accepted/In Press date: 8 April 2022
Published date: 25 April 2022
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Funding Information:
This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10‐year follow‐up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995‐1998), No 362 (1998‐2001), No 01/012 (2001‐2004), No 04/014 (2004‐2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004‐current), the North West Lung Centre Charity (1997‐current), and the Medical Research Council (MRC) G0601361 (2007‐2012), MR/K002449/1 (2013‐2014), and MR/L012693/1 (2014‐2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.
Funding Information:
This work was supported by the NIHR Southampton Biomedical Research Centre and a University of Southampton Presidential Research Studentship. The 10-year follow-up of the IOWBC was supported by the National Asthma Campaign, UK (Grant No 364). MAAS was supported by the Asthma UK Grants No 301 (1995-1998), No 362 (1998-2001), No 01/012 (2001-2004), No 04/014 (2004-2007), BMA James Trust (2005), and the JP Moulton Charitable Foundation (2004-current), the North West Lung Centre Charity (1997-current), and the Medical Research Council (MRC) G0601361 (2007-2012), MR/K002449/1 (2013-2014), and MR/L012693/1 (2014-2018). UNICORN (Unified Cohorts Research Network): Disaggregating asthma MR/S025340/1. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. GWAS data were generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. RG is in part funded through Wellcome Trust Strategic Award 108818/15/Z.
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Keywords:
ALSPAC, PRS-by-environment interactions, childhood asthma, meta-analysis, parental smoking, polygenic risk score
Identifiers
Local EPrints ID: 457106
URI: http://eprints.soton.ac.uk/id/eprint/457106
ISSN: 0905-6157
PURE UUID: c88a5359-b423-4628-9b2e-ebbcd9f04fb8
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Date deposited: 24 May 2022 16:37
Last modified: 17 Mar 2024 07:17
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Contributors
Author:
Dilini M. Kothalawala
Author:
Veronique B. N. Weiss
Author:
Latha Kadalayil
Author:
Raquel Granell
Author:
John A. Curtin
Author:
Clare S. Murray
Author:
Angela Simpson
Author:
Adnan Custovic
Author:
Faisal I. Rezwan
Author:
Syed Hasan Arshad
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