Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment
Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment
Despite the promise of intranasal oxytocin (OT) for modulating social behavior, recent work has provided mixed results. This may
relate to suboptimal drug deposition achieved with conventional nasal sprays, inter-individual differences in nasal physiology and a
poor understanding of how intranasal OT is delivered to the brain in humans. Delivering OT using a novel ‘Breath Powered’ nasal
device previously shown to enhance deposition in intranasal sites targeted for nose-to-brain transport, we evaluated dosedependent effects on social cognition, compared response with intravenous (IV) administration of OT, and assessed nasal cavity
dimensions using acoustic rhinometry. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy
male adults completing four single-dose treatments (intranasal 8 IU (international units) or 24 IU OT, 1 IU OT IV and placebo). The
primary outcome was social cognition measured by emotional ratings of facial images. Secondary outcomes included the
pharmacokinetics of OT, vasopressin and cortisol in blood and the association between nasal cavity dimensions and emotional
ratings. Despite the fact that all the treatments produced similar plasma OT increases compared with placebo, there was a main
effect of treatment on anger ratings of emotionally ambiguous faces. Pairwise comparisons revealed decreased ratings after 8 IU OT
in comparison to both placebo and 24 IU OT. In addition, there was an inverse relationship between nasal valve dimensions and
anger ratings of ambiguous faces after 8-IU OT treatment. These findings provide support for a direct nose-to-brain effect,
independent of blood absorption, of low-dose OT delivered from a Breath Powered device.
1-9
Poppy, Claire
2e967e2a-2a43-470f-b1d1-7514f097db8d
Quintana, Daniel
d0c6fa99-788a-4d55-802b-6277e61ccd77
14 July 2015
Poppy, Claire
2e967e2a-2a43-470f-b1d1-7514f097db8d
Quintana, Daniel
d0c6fa99-788a-4d55-802b-6277e61ccd77
Poppy, Claire and Quintana, Daniel
(2015)
Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment.
Translational Psychiatry, 5 (e602), .
(doi:10.1038/tp.2015.93).
Abstract
Despite the promise of intranasal oxytocin (OT) for modulating social behavior, recent work has provided mixed results. This may
relate to suboptimal drug deposition achieved with conventional nasal sprays, inter-individual differences in nasal physiology and a
poor understanding of how intranasal OT is delivered to the brain in humans. Delivering OT using a novel ‘Breath Powered’ nasal
device previously shown to enhance deposition in intranasal sites targeted for nose-to-brain transport, we evaluated dosedependent effects on social cognition, compared response with intravenous (IV) administration of OT, and assessed nasal cavity
dimensions using acoustic rhinometry. We adopted a randomized, double-blind, double-dummy, crossover design, with 16 healthy
male adults completing four single-dose treatments (intranasal 8 IU (international units) or 24 IU OT, 1 IU OT IV and placebo). The
primary outcome was social cognition measured by emotional ratings of facial images. Secondary outcomes included the
pharmacokinetics of OT, vasopressin and cortisol in blood and the association between nasal cavity dimensions and emotional
ratings. Despite the fact that all the treatments produced similar plasma OT increases compared with placebo, there was a main
effect of treatment on anger ratings of emotionally ambiguous faces. Pairwise comparisons revealed decreased ratings after 8 IU OT
in comparison to both placebo and 24 IU OT. In addition, there was an inverse relationship between nasal valve dimensions and
anger ratings of ambiguous faces after 8-IU OT treatment. These findings provide support for a direct nose-to-brain effect,
independent of blood absorption, of low-dose OT delivered from a Breath Powered device.
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Oxytocin paper_Translational Psychiatry
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Accepted/In Press date: 2 June 2015
Published date: 14 July 2015
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Local EPrints ID: 457585
URI: http://eprints.soton.ac.uk/id/eprint/457585
PURE UUID: d691b0c0-0343-4dfd-bed0-8ad294772266
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Date deposited: 13 Jun 2022 16:48
Last modified: 16 Mar 2024 17:46
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Daniel Quintana
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