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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Multispectral sensing of biological liquids with hollow-core microstructured optical fibres
Multispectral sensing of biological liquids with hollow-core microstructured optical fibres
The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous
measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity
up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine
serum albumin and show that the accuracy meets clinical needs
Fibre optics, Optical sensors
2095-5545
Ermatov, Timur
aa23c380-e953-438d-aff3-a8aab7cd53d6
Noskov, Roman
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Machnev, Andrey
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Gnusov, Ivan
973d41be-2823-4164-9f3e-4332d2818f07
Atkin, Vsevolod
980d8370-3717-499f-bddf-8d47d0ce6b76
Lazareva, Ekaterina
56f0d432-2c4d-4f6a-b3d7-108cd5ba6305
German, Sergei V
b3dab111-c917-422a-8687-a4c228aead56
Kosolobov, Sergey
61560580-d8d8-4b76-8588-8bb10bd1aead
Zatsepin, Timofei S
f98e9e7a-18b2-4a6a-9f12-1bcdd8808c89
Sergeeva, Olga
58c500c0-ddae-4dbf-ac44-17baaf55bb27
Skibina, Julia S
315af992-52ed-4dd7-8253-7452014b70b0
Ginzburg, Pavel
d777de36-b51f-47fc-9e25-20df5a22079f
Tuchin, Valery V
867d7fa2-c716-43e2-b951-5680c5dfb939
Lagoudakis, Pavlos
ea50c228-f006-4edf-8459-60015d961bbf
Gorin, Dmitry A
56a21974-dcdd-40be-8b47-cffcba3cdfe0
Ermatov, Timur
aa23c380-e953-438d-aff3-a8aab7cd53d6
Noskov, Roman
b3fc6e7b-2ab2-4ec0-93b7-cf8167a489ce
Machnev, Andrey
59aac2e8-8114-4e2b-abac-0ca403bebeeb
Gnusov, Ivan
973d41be-2823-4164-9f3e-4332d2818f07
Atkin, Vsevolod
980d8370-3717-499f-bddf-8d47d0ce6b76
Lazareva, Ekaterina
56f0d432-2c4d-4f6a-b3d7-108cd5ba6305
German, Sergei V
b3dab111-c917-422a-8687-a4c228aead56
Kosolobov, Sergey
61560580-d8d8-4b76-8588-8bb10bd1aead
Zatsepin, Timofei S
f98e9e7a-18b2-4a6a-9f12-1bcdd8808c89
Sergeeva, Olga
58c500c0-ddae-4dbf-ac44-17baaf55bb27
Skibina, Julia S
315af992-52ed-4dd7-8253-7452014b70b0
Ginzburg, Pavel
d777de36-b51f-47fc-9e25-20df5a22079f
Tuchin, Valery V
867d7fa2-c716-43e2-b951-5680c5dfb939
Lagoudakis, Pavlos
ea50c228-f006-4edf-8459-60015d961bbf
Gorin, Dmitry A
56a21974-dcdd-40be-8b47-cffcba3cdfe0

Ermatov, Timur, Noskov, Roman, Machnev, Andrey, Gnusov, Ivan, Atkin, Vsevolod, Lazareva, Ekaterina, German, Sergei V, Kosolobov, Sergey, Zatsepin, Timofei S, Sergeeva, Olga, Skibina, Julia S, Ginzburg, Pavel, Tuchin, Valery V, Lagoudakis, Pavlos and Gorin, Dmitry A (2020) Multispectral sensing of biological liquids with hollow-core microstructured optical fibres. Light: Science & Applications, 9, [173]. (doi:10.1038/s41377-020-00410-8).

Record type: Article

Abstract

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance. This common strategy, however, disregards the promising possibility of simultaneous
measurements of a bioanalyte’s refractive index over a broadband spectral domain. Here, we address this issue by introducing the approach of in-fibre multispectral optical sensing (IMOS). The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells. IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths, with a sensitivity
up to ~3000 nm per refractive index unit (RIU) and a figure of merit reaching 99 RIU−1 in the visible and near-infra-red spectral ranges. We apply this technique to determine the concentration and refractive index dispersion for bovine
serum albumin and show that the accuracy meets clinical needs

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More information

Accepted/In Press date: 24 September 2020
Published date: 10 October 2020
Keywords: Fibre optics, Optical sensors

Identifiers

Local EPrints ID: 457779
URI: http://eprints.soton.ac.uk/id/eprint/457779
ISSN: 2095-5545
PURE UUID: aac8761c-3840-4b25-bf96-3a4158c38ad2
ORCID for Pavlos Lagoudakis: ORCID iD orcid.org/0000-0002-3557-5299

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Date deposited: 16 Jun 2022 16:54
Last modified: 17 Jun 2022 01:36

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Contributors

Author: Timur Ermatov
Author: Roman Noskov
Author: Andrey Machnev
Author: Ivan Gnusov
Author: Vsevolod Atkin
Author: Ekaterina Lazareva
Author: Sergei V German
Author: Sergey Kosolobov
Author: Timofei S Zatsepin
Author: Olga Sergeeva
Author: Julia S Skibina
Author: Pavel Ginzburg
Author: Valery V Tuchin
Author: Pavlos Lagoudakis ORCID iD
Author: Dmitry A Gorin

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