Oxidative stress and Redox-Modulating Therapeutics in inflammatory bowel disease
Oxidative stress and Redox-Modulating Therapeutics in inflammatory bowel disease
Inflammatory bowel disease (IBD) is associated with the production of reactive species that target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage, ion transport, intermediary metabolism, and mitochondrial function. Precursors of reactive species are derived from organic and inorganic compounds and their cofactors, including amino acids, vitamins, oxygen, nitrite, and sulfate. Nutrition and the gut microbiome fuel this process to a significant extent. The production of reactive species in IBD is reflected by a reduction in systemic free thiols, the major components of the antioxidant machinery. Systemic free thiols are amenable to nutritional or therapeutic intervention. This opens up future avenues for therapeutic modulation of redox status in IBD.
Animals, Anti-Inflammatory Agents/pharmacology, Gene Expression Regulation, Humans, Inflammatory Bowel Diseases/drug therapy, Metabolome, Metabolomics/methods, Oxidation-Reduction/drug effects, Oxidative Stress/drug effects, Reactive Oxygen Species/metabolism, Sulfhydryl Compounds/pharmacology
1034-1046
Bourgonje, Arno R
115e3b3a-f1b0-4d6f-ace1-8329514fa17a
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Faber, Klaas Nico
c47f6f01-7cb1-40c0-94bb-a0dba94cf4fc
Pasch, Andreas
5f5d9b34-4d9e-40a4-9326-fa1cd352717d
Dijkstra, Gerard
eb02d123-dc70-403e-ab77-633948f84f5e
van Goor, Harry
fadc9a49-233e-40c3-9e05-8713ffbc02e5
1 November 2020
Bourgonje, Arno R
115e3b3a-f1b0-4d6f-ace1-8329514fa17a
Feelisch, Martin
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Faber, Klaas Nico
c47f6f01-7cb1-40c0-94bb-a0dba94cf4fc
Pasch, Andreas
5f5d9b34-4d9e-40a4-9326-fa1cd352717d
Dijkstra, Gerard
eb02d123-dc70-403e-ab77-633948f84f5e
van Goor, Harry
fadc9a49-233e-40c3-9e05-8713ffbc02e5
Bourgonje, Arno R, Feelisch, Martin, Faber, Klaas Nico, Pasch, Andreas, Dijkstra, Gerard and van Goor, Harry
(2020)
Oxidative stress and Redox-Modulating Therapeutics in inflammatory bowel disease.
Trends in Molecular Medicine, 26 (11), .
(doi:10.1016/j.molmed.2020.06.006).
Abstract
Inflammatory bowel disease (IBD) is associated with the production of reactive species that target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage, ion transport, intermediary metabolism, and mitochondrial function. Precursors of reactive species are derived from organic and inorganic compounds and their cofactors, including amino acids, vitamins, oxygen, nitrite, and sulfate. Nutrition and the gut microbiome fuel this process to a significant extent. The production of reactive species in IBD is reflected by a reduction in systemic free thiols, the major components of the antioxidant machinery. Systemic free thiols are amenable to nutritional or therapeutic intervention. This opens up future avenues for therapeutic modulation of redox status in IBD.
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More information
e-pub ahead of print date: 30 June 2020
Published date: 1 November 2020
Keywords:
Animals, Anti-Inflammatory Agents/pharmacology, Gene Expression Regulation, Humans, Inflammatory Bowel Diseases/drug therapy, Metabolome, Metabolomics/methods, Oxidation-Reduction/drug effects, Oxidative Stress/drug effects, Reactive Oxygen Species/metabolism, Sulfhydryl Compounds/pharmacology
Identifiers
Local EPrints ID: 457810
URI: http://eprints.soton.ac.uk/id/eprint/457810
ISSN: 1471-4914
PURE UUID: 22fd85a7-61d6-4c41-8d93-48dd3b936a95
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Date deposited: 16 Jun 2022 17:13
Last modified: 17 Mar 2024 03:27
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Contributors
Author:
Arno R Bourgonje
Author:
Klaas Nico Faber
Author:
Andreas Pasch
Author:
Gerard Dijkstra
Author:
Harry van Goor
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