Associations between mental and physical conditions in children and adolescents: an umbrella review
Associations between mental and physical conditions in children and adolescents: an umbrella review
We mapped the evidence on the type and strength of associations between a broad range of mental and physical conditions in children and adolescents, by carrying out an umbrella review, i.e., a quantitative synthesis of previous systematic reviews and meta-analyses. We also assessed to which extent the links between mental and physical conditions vary across disorders or, by contrast, are transdiagnostic. Based on a pre-established protocol, we retained 45 systematic reviews/meta-analyses, encompassing around 12.5 million of participants. In analyses limited to the most rigorous estimates, we found evidence for the following associations: ADHD-asthma, ADHD-obesity, and depression-asthma. A transdiagnostic association was confirmed between asthma and anxiety/ASD/depression/bipolar disorder, between obesity and ADHD/ASD/depression, and between dermatitis and ASD/ADHD. We conclude that obesity and allergic conditions are likely to be associated with mental disorders in children and adolescents. Our results can help clinicians explore potential links between mental and physical conditions in children/adolescent and provide a road map for future studies aimed at shading light on the underlying factors.
Mental, Physical, Transdiagnostic, Umbrella review, meta-analysis
Arrondo, Gonzalo
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Solmi, Marco
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Dragioti, Elena
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Eudave, Luis
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Ruiz-Goikoetxea, Maite
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Ciaurriz-Larraz, Amaia M
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Magallon, Sara
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Carvalho, Andre F
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Cipriani, Andrea
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Fusar-Poli, Paolo
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Larsson, Henrik
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Correll, Christoph U
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Cortese, Samuele
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June 2022
Arrondo, Gonzalo
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Solmi, Marco
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Dragioti, Elena
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Eudave, Luis
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Ruiz-Goikoetxea, Maite
e751449f-8f23-4c6c-8a91-48383398f7de
Ciaurriz-Larraz, Amaia M
23e29afb-d122-4432-a5e2-8cdfc0f8a2f7
Magallon, Sara
9b075c36-f41b-4987-9952-a124c6ba800d
Carvalho, Andre F
3c35be2b-3f7e-48e9-8163-389c9fd5048f
Cipriani, Andrea
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Fusar-Poli, Paolo
62c59ab3-36bc-446b-9672-5565fdc76cf5
Larsson, Henrik
f34c9fb2-d7d6-4932-a924-aef5ba36d4e0
Correll, Christoph U
d1a6c4a7-3911-4ffb-9d9d-4d70f6b574b1
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Arrondo, Gonzalo, Solmi, Marco, Dragioti, Elena, Eudave, Luis, Ruiz-Goikoetxea, Maite, Ciaurriz-Larraz, Amaia M, Magallon, Sara, Carvalho, Andre F, Cipriani, Andrea, Fusar-Poli, Paolo, Larsson, Henrik, Correll, Christoph U and Cortese, Samuele
(2022)
Associations between mental and physical conditions in children and adolescents: an umbrella review.
Neuroscience and Biobehavioral Reviews, 137, [104662].
(doi:10.1016/j.neubiorev.2022.104662).
Abstract
We mapped the evidence on the type and strength of associations between a broad range of mental and physical conditions in children and adolescents, by carrying out an umbrella review, i.e., a quantitative synthesis of previous systematic reviews and meta-analyses. We also assessed to which extent the links between mental and physical conditions vary across disorders or, by contrast, are transdiagnostic. Based on a pre-established protocol, we retained 45 systematic reviews/meta-analyses, encompassing around 12.5 million of participants. In analyses limited to the most rigorous estimates, we found evidence for the following associations: ADHD-asthma, ADHD-obesity, and depression-asthma. A transdiagnostic association was confirmed between asthma and anxiety/ASD/depression/bipolar disorder, between obesity and ADHD/ASD/depression, and between dermatitis and ASD/ADHD. We conclude that obesity and allergic conditions are likely to be associated with mental disorders in children and adolescents. Our results can help clinicians explore potential links between mental and physical conditions in children/adolescent and provide a road map for future studies aimed at shading light on the underlying factors.
Text
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Accepted/In Press date: 8 April 2022
e-pub ahead of print date: 12 April 2022
Published date: June 2022
Additional Information:
Acknowledgements
GA was supported by the Spanish Ministry of Science, Innovation and Universities to facilitate the mobility of researchers to foreign higher education and research centers (Ref. CAS19/00249). MR was supported by the 2019 Senior Grant from the Medical Association of Navarre. SM is supported by the European Social Fund and the Spanish Research Agency (Ramón y Cajal-2017-22060). AC is supported by the NIHR Oxford Cognitive Health Clinical Research Facility, by an NIHR Research Professorship (Grant number RP-2017-08-ST2-006), by the NIHR Oxford and Thames Valley Applied Research Collaboration, and by the NIHR Oxford Health Biomedical Research Centre (Grant number BRC-1215-20005). The views expressed are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the UK Department of Health.
Keywords:
Mental, Physical, Transdiagnostic, Umbrella review, meta-analysis
Identifiers
Local EPrints ID: 457926
URI: http://eprints.soton.ac.uk/id/eprint/457926
ISSN: 0149-7634
PURE UUID: d39184ff-c490-47c4-bbce-bd6de79e8d5c
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Date deposited: 22 Jun 2022 16:45
Last modified: 17 Mar 2024 03:37
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Contributors
Author:
Gonzalo Arrondo
Author:
Marco Solmi
Author:
Elena Dragioti
Author:
Luis Eudave
Author:
Maite Ruiz-Goikoetxea
Author:
Amaia M Ciaurriz-Larraz
Author:
Sara Magallon
Author:
Andre F Carvalho
Author:
Andrea Cipriani
Author:
Paolo Fusar-Poli
Author:
Henrik Larsson
Author:
Christoph U Correll
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