HIV-associated alterations of the biophysical features of maternal antibodies correlate with their reduced transfer across the placenta
HIV-associated alterations of the biophysical features of maternal antibodies correlate with their reduced transfer across the placenta
Background
Human Immunodeficiency Virus (HIV) infection during pregnancy is associated with reduced transplacental transfer of maternal antibodies and increased risk of severe infections in children who are exposed and uninfected with HIV (CHEU). The basis of this reduced transfer of maternal immunity has not yet been defined but could involve modifications in the biophysical features of antibodies.
Objective
To assess the impact of maternal HIV infection on the biophysical features of serum IgG and transplacental antibody transfer.
Methods
Maternal serum IgG subclass levels, Fc glycosylation, Fc Receptor (FcR) binding, and transplacental transfer of pathogen-specific maternal IgG were measured in pregnant women living with HIV (WWH) and pregnant women testing negative for HIV (WNH) in Cape Town, South Africa.
Results
Maternal antibody profiles were strikingly different between pregnant WWH and WNH. Antibody binding to FcγR2a and FcγR2b, IgG1 and IgG3 antibodies, and agalactosylated antibodies were all elevated in WLHIV, whereas digalactosylated and sialylated antibodies were reduced as compared to pregnant WNH. Antibody features that were elevated in WWH were also correlated with reduced transplacental transfer of vaccine antigen-specific antibodies.
Conclusion
HIV infection is associated with marked alterations of biophysical features of maternal IgG and reduced placental transfer—potentially impairing antimicrobial immunity.
Fc receptors, HIV infection, IgG, pregnancy, transplacental transfer
1441-1450
Taylor, Sean A.
33bf9109-021e-435e-a775-cdf67f42e656
Sharma, Shilpee
7f308e71-63fc-41a0-8071-f540e761725a
Remmel, Christopher A. L.
11393ade-da1e-48ff-badf-70528d30e87d
Holder, Beth
7be76194-2813-4e5a-b0d4-9f34511c7799
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Marchant, Arnaud
7631707e-d29a-4a4e-ab92-2bcd4f54a411
Ackerman, Margaret E.
b4a13358-a1ad-4b11-867b-e3102c2c9961
17 October 2022
Taylor, Sean A.
33bf9109-021e-435e-a775-cdf67f42e656
Sharma, Shilpee
7f308e71-63fc-41a0-8071-f540e761725a
Remmel, Christopher A. L.
11393ade-da1e-48ff-badf-70528d30e87d
Holder, Beth
7be76194-2813-4e5a-b0d4-9f34511c7799
Jones, Christine E.
48229079-8b58-4dcb-8374-d9481fe7b426
Marchant, Arnaud
7631707e-d29a-4a4e-ab92-2bcd4f54a411
Ackerman, Margaret E.
b4a13358-a1ad-4b11-867b-e3102c2c9961
Taylor, Sean A., Sharma, Shilpee, Remmel, Christopher A. L., Holder, Beth, Jones, Christine E., Marchant, Arnaud and Ackerman, Margaret E.
(2022)
HIV-associated alterations of the biophysical features of maternal antibodies correlate with their reduced transfer across the placenta.
The Journal of Infectious Diseases, 226 (8), .
(doi:10.1093/infdis/jiac222).
Abstract
Background
Human Immunodeficiency Virus (HIV) infection during pregnancy is associated with reduced transplacental transfer of maternal antibodies and increased risk of severe infections in children who are exposed and uninfected with HIV (CHEU). The basis of this reduced transfer of maternal immunity has not yet been defined but could involve modifications in the biophysical features of antibodies.
Objective
To assess the impact of maternal HIV infection on the biophysical features of serum IgG and transplacental antibody transfer.
Methods
Maternal serum IgG subclass levels, Fc glycosylation, Fc Receptor (FcR) binding, and transplacental transfer of pathogen-specific maternal IgG were measured in pregnant women living with HIV (WWH) and pregnant women testing negative for HIV (WNH) in Cape Town, South Africa.
Results
Maternal antibody profiles were strikingly different between pregnant WWH and WNH. Antibody binding to FcγR2a and FcγR2b, IgG1 and IgG3 antibodies, and agalactosylated antibodies were all elevated in WLHIV, whereas digalactosylated and sialylated antibodies were reduced as compared to pregnant WNH. Antibody features that were elevated in WWH were also correlated with reduced transplacental transfer of vaccine antigen-specific antibodies.
Conclusion
HIV infection is associated with marked alterations of biophysical features of maternal IgG and reduced placental transfer—potentially impairing antimicrobial immunity.
Text
R1 Taylor Submitted
- Accepted Manuscript
More information
Accepted/In Press date: 27 May 2022
Published date: 17 October 2022
Additional Information:
Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Keywords:
Fc receptors, HIV infection, IgG, pregnancy, transplacental transfer
Identifiers
Local EPrints ID: 457972
URI: http://eprints.soton.ac.uk/id/eprint/457972
ISSN: 0022-1899
PURE UUID: ee8d629a-902d-4654-9373-eb3a770f1c9f
Catalogue record
Date deposited: 23 Jun 2022 17:55
Last modified: 17 Mar 2024 07:21
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Contributors
Author:
Sean A. Taylor
Author:
Shilpee Sharma
Author:
Christopher A. L. Remmel
Author:
Beth Holder
Author:
Arnaud Marchant
Author:
Margaret E. Ackerman
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