Comparison of the susceptibility of the red fox (Vulpes vulpes) to a vaccinia-rabies recombinant virus and to cowpox virus
Comparison of the susceptibility of the red fox (Vulpes vulpes) to a vaccinia-rabies recombinant virus and to cowpox virus
Sylvatic rabies can be efficiently controlled by vaccination of foxes with a vaccinia-rabies recombinant virus. However, the risk of recombination between the engineered vaccine virus and other orthopoxviruses endemic in wildlife, such as cowpox virus, still needs to be investigated. In this study, foxes inoculated orally and intradermally with cowpox virus were found to be not very susceptible to cowpox virus, which was isolated from only the oropharynx and tonsils, at low titre and for only five days after inoculation. Thus the risk of recombination between these viruses in foxes is very low.
Rabies virus, cowpox virus, recombination risk
215-219
Boulanger, Denise
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Brochier, B.
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Crouch, A.
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Bennett, M.
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Gaskell, R.M.
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Baxby, D.
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Pastoret, P.P.
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January 1995
Boulanger, Denise
c226ad99-9c9a-485a-b480-42fb8799120f
Brochier, B.
4722c29b-d33c-4f71-a850-f606017457e5
Crouch, A.
c3275433-0732-435c-8d2b-10c34ddf83b4
Bennett, M.
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Gaskell, R.M.
99caca72-f0a7-4467-8ea1-3b3656da1bad
Baxby, D.
546702bd-7105-4c5b-9f4c-8505f035bf2c
Pastoret, P.P.
5dacdfb0-ce58-43ba-bd1d-c7eda6ac898b
Boulanger, Denise, Brochier, B., Crouch, A., Bennett, M., Gaskell, R.M., Baxby, D. and Pastoret, P.P.
(1995)
Comparison of the susceptibility of the red fox (Vulpes vulpes) to a vaccinia-rabies recombinant virus and to cowpox virus.
Vaccine, 13 (2), .
(doi:10.1016/0264-410X(95)93139-Z).
Abstract
Sylvatic rabies can be efficiently controlled by vaccination of foxes with a vaccinia-rabies recombinant virus. However, the risk of recombination between the engineered vaccine virus and other orthopoxviruses endemic in wildlife, such as cowpox virus, still needs to be investigated. In this study, foxes inoculated orally and intradermally with cowpox virus were found to be not very susceptible to cowpox virus, which was isolated from only the oropharynx and tonsils, at low titre and for only five days after inoculation. Thus the risk of recombination between these viruses in foxes is very low.
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Published date: January 1995
Additional Information:
Copyright © 1995 Published by Elsevier Ltd.
Keywords:
Rabies virus, cowpox virus, recombination risk
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Local EPrints ID: 458056
URI: http://eprints.soton.ac.uk/id/eprint/458056
ISSN: 0264-410X
PURE UUID: 5579b68f-b568-41cd-a4c3-e9c7e0cb17e3
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Date deposited: 27 Jun 2022 17:11
Last modified: 17 Mar 2024 02:57
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Contributors
Author:
Denise Boulanger
Author:
B. Brochier
Author:
A. Crouch
Author:
M. Bennett
Author:
R.M. Gaskell
Author:
D. Baxby
Author:
P.P. Pastoret
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