Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women
Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women
Aims: Despite a higher prevalence of overweight/obesity in Black South African women compared to men, the prevalence of type 2 diabetes (T2D) does not differ. We explored if this could be due to sex differences in insulin sensitivity, clearance and/or beta-cell function and also sex-specific associations with total and regional adiposity.
Methods: This cross-sectional study included 804 Black South African men (n = 388) and women (n = 416). Dual-energy X-ray absorptiometry was used to measure total and regional adiposity. Insulin sensitivity (Matsuda index), secretion (C-peptide index) and clearance (C-peptide/insulin ratio) were estimated from an oral glucose tolerance test.
Results: After adjusting for sex differences in the fat mass index, men were less insulin sensitive and had lower beta-cell function than women (P < 0.001), with the strength of the associations with measures of total and central adiposity being greater in men than women (P < 0.001 for interactions). Further, the association between total adiposity and T2D risk was also greater in men than women (relative risk ratio (95% CI): 2.05 (1.42-2.96), P < 0.001 vs 1.38 (1.03-1.85), P = 0.031).
Conclusion: With increasing adiposity, particularly increased centralisation of body fat linked to decreased insulin sensitivity and beta-cell function, Black African men are at greater risk for T2D than their female counterparts.
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Kufe, Clement N
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Micklesfield, Lisa K
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Masemola, Maphoko
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Chikowore, Tinashe
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Kengne, Andre P
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Karpe, Fredrik
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Norris, Shane A
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Crowther, Nigel J
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Olsson, Tommy
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Goedecke, Julia H
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1 May 2022
Kufe, Clement N
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Micklesfield, Lisa K
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Masemola, Maphoko
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Chikowore, Tinashe
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Kengne, Andre P
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Karpe, Fredrik
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Norris, Shane A
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Crowther, Nigel J
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Olsson, Tommy
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Goedecke, Julia H
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Kufe, Clement N, Micklesfield, Lisa K, Masemola, Maphoko, Chikowore, Tinashe, Kengne, Andre P, Karpe, Fredrik, Norris, Shane A, Crowther, Nigel J, Olsson, Tommy and Goedecke, Julia H
(2022)
Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women.
European journal of endocrinology, 168 (5), .
(doi:10.1530/EJE-21-0527).
Abstract
Aims: Despite a higher prevalence of overweight/obesity in Black South African women compared to men, the prevalence of type 2 diabetes (T2D) does not differ. We explored if this could be due to sex differences in insulin sensitivity, clearance and/or beta-cell function and also sex-specific associations with total and regional adiposity.
Methods: This cross-sectional study included 804 Black South African men (n = 388) and women (n = 416). Dual-energy X-ray absorptiometry was used to measure total and regional adiposity. Insulin sensitivity (Matsuda index), secretion (C-peptide index) and clearance (C-peptide/insulin ratio) were estimated from an oral glucose tolerance test.
Results: After adjusting for sex differences in the fat mass index, men were less insulin sensitive and had lower beta-cell function than women (P < 0.001), with the strength of the associations with measures of total and central adiposity being greater in men than women (P < 0.001 for interactions). Further, the association between total adiposity and T2D risk was also greater in men than women (relative risk ratio (95% CI): 2.05 (1.42-2.96), P < 0.001 vs 1.38 (1.03-1.85), P = 0.031).
Conclusion: With increasing adiposity, particularly increased centralisation of body fat linked to decreased insulin sensitivity and beta-cell function, Black African men are at greater risk for T2D than their female counterparts.
Text
[1479683X - European Journal of Endocrinology] Increased risk for type 2 diabetes in relation to adiposity in middle-aged Black South African men compared to women
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Accepted/In Press date: 28 February 2022
e-pub ahead of print date: 23 March 2022
Published date: 1 May 2022
Additional Information:
Funding Information:
The study was jointly funded by the South African Medical Research Council (MRC) from South African National Department of Health, MRC UK (via the Newton Fund) and GSK Africa Non-Communicable Disease Open Lab (via a supporting Grant project Number: ES/N013891/1) and South
Funding Information:
international training fellow supported by the Wellcome Trust grant (grant
Funding Information:
African National Research Foundation (Grant no: U 阀D:98561). T C is an
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© 2022 The authors.
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Local EPrints ID: 458120
URI: http://eprints.soton.ac.uk/id/eprint/458120
ISSN: 0804-4643
PURE UUID: eba5040d-fc74-4d03-bdd1-be6d10a9d804
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Date deposited: 28 Jun 2022 17:17
Last modified: 17 Mar 2024 03:57
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Author:
Clement N Kufe
Author:
Lisa K Micklesfield
Author:
Maphoko Masemola
Author:
Tinashe Chikowore
Author:
Andre P Kengne
Author:
Fredrik Karpe
Author:
Nigel J Crowther
Author:
Tommy Olsson
Author:
Julia H Goedecke
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