The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health.
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health.
The placental exposome represents the sum of all placental exposures, and through its influence on placental function can affect an individual's susceptibility to cardio-metabolic disease later in life. The placental exposome includes direct exposures during gestation, as well as those prior to gestation that affect the gametes or aspects of maternal physiology that influence placental function. This review will discuss the evidence for placental responses to environmental signals and its involvement in programming offspring health. A wide range of exposures may influence the placenta including maternal metabolic and endocrine status, nutrition, stress and toxins. Epigenetic changes within the placenta induced by these exposures may mediate persistent effects on placental function. Identifying which exposures are most influential in terms of placental function and offspring health is key to focusing future research and developing stratified and personalised interventions.
Cleal, Jane
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, Kirsten
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
October 2022
Cleal, Jane
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, Kirsten
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, Jane, Poore, Kirsten and Lewis, Rohan
(2022)
The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health.
Molecular Aspects of Medicine, 87, [101095].
(doi:10.1016/j.mam.2022.101095).
Abstract
The placental exposome represents the sum of all placental exposures, and through its influence on placental function can affect an individual's susceptibility to cardio-metabolic disease later in life. The placental exposome includes direct exposures during gestation, as well as those prior to gestation that affect the gametes or aspects of maternal physiology that influence placental function. This review will discuss the evidence for placental responses to environmental signals and its involvement in programming offspring health. A wide range of exposures may influence the placenta including maternal metabolic and endocrine status, nutrition, stress and toxins. Epigenetic changes within the placenta induced by these exposures may mediate persistent effects on placental function. Identifying which exposures are most influential in terms of placental function and offspring health is key to focusing future research and developing stratified and personalised interventions.
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Placental Exposome
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e-pub ahead of print date: 18 April 2022
Published date: October 2022
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Local EPrints ID: 458157
URI: http://eprints.soton.ac.uk/id/eprint/458157
ISSN: 1872-9452
PURE UUID: 4c0bf6d2-e57f-4b1a-b09a-a4adfe62ddae
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Date deposited: 29 Jun 2022 17:26
Last modified: 17 Aug 2024 01:38
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