Objective estimation of endolymphatic hydrops using auditory brainstem response measures
Objective estimation of endolymphatic hydrops using auditory brainstem response measures
The `true' Menié`e's patient is believed to have a condition known as endolymphatic hydrops. The diagnosis of Menié`e's disease is usually achieved by a clinicians subjective analysis of patients symptoms, hence any objective measure of endolymphatic hydrops will improve the detection and management of these patients. Using derived auditory brainstem response (ABR) measures, this study has shown that the travelling wave velocity (TWV) in Menié`e's patients is increased in the high frequency region of the cochlea. This is believed to be due to increased pressure in the scala media (endolymphatic hydrops) increasing the stiffness of the basilar membrane. The derived ABR procedure for measuring TWV is too time consuming to be used as a practical clinical technique. A shorter clinical version of the travelling wave velocity estimation test was therefore developed, in which wave V latency differences between two high-pass masked auditory brainstem responses were used to estimate TWV. This measure has been called delta V. Verification of this technique was obtained by a glycerol dehydration procedure during which, in all the patients who were successfully dehydrated, delta V changed from an abnormal to a more normal value. More importantly the technique has been successfully applied in assessing the effect of medication and corrective surgical procedures on the endolymphatic pressure in Menié`e's patients. The test provides a sensitive and objective measure of the presence of endolymphatic hydrops which can be used in diagnosing the `true' Menié`e's patient. As a new technique it has a definite role in the assessment of patients who may be thought to have endolymphatic hydrops and in studying the onset and progression of Menié`e's disease.
University of Southampton
1991
Farrell, Gary
(1991)
Objective estimation of endolymphatic hydrops using auditory brainstem response measures.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The `true' Menié`e's patient is believed to have a condition known as endolymphatic hydrops. The diagnosis of Menié`e's disease is usually achieved by a clinicians subjective analysis of patients symptoms, hence any objective measure of endolymphatic hydrops will improve the detection and management of these patients. Using derived auditory brainstem response (ABR) measures, this study has shown that the travelling wave velocity (TWV) in Menié`e's patients is increased in the high frequency region of the cochlea. This is believed to be due to increased pressure in the scala media (endolymphatic hydrops) increasing the stiffness of the basilar membrane. The derived ABR procedure for measuring TWV is too time consuming to be used as a practical clinical technique. A shorter clinical version of the travelling wave velocity estimation test was therefore developed, in which wave V latency differences between two high-pass masked auditory brainstem responses were used to estimate TWV. This measure has been called delta V. Verification of this technique was obtained by a glycerol dehydration procedure during which, in all the patients who were successfully dehydrated, delta V changed from an abnormal to a more normal value. More importantly the technique has been successfully applied in assessing the effect of medication and corrective surgical procedures on the endolymphatic pressure in Menié`e's patients. The test provides a sensitive and objective measure of the presence of endolymphatic hydrops which can be used in diagnosing the `true' Menié`e's patient. As a new technique it has a definite role in the assessment of patients who may be thought to have endolymphatic hydrops and in studying the onset and progression of Menié`e's disease.
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Published date: 1991
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Local EPrints ID: 458300
URI: http://eprints.soton.ac.uk/id/eprint/458300
PURE UUID: 4d2089b8-a624-4f82-9b4f-d9a676019f3f
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Date deposited: 04 Jul 2022 16:46
Last modified: 04 Jul 2022 16:46
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Author:
Gary Farrell
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