The natural history of allergic diseases in children : a prospective clinical, immunological and environmental study
The natural history of allergic diseases in children : a prospective clinical, immunological and environmental study
To investigate the natural history of allergic disease in children and to identify potential risk factor, a cohort of 67 babies (35 boys) at risk of developing atopic disorders were followed prospectively for 11 years. On the basis of allergen skin testing 35 were atopic (skin weal >4mm), its expression increased with age. The yearly period prevalence of hay fever increased with age, that of eczema declined, while that for wheeze showed a bimodal distribution with a peak prior to 2 and a gradual increase thereafter. These conditions were heterogeneous, with atopy being associated with their persistence. The children with asthma (current wheeze and bronchial hyperresponsiveness to histamine) at 11 were sensitised to indoor allergens, predominantly those from the house dust mite (Der p I) (p<0.001). At age 11, parental atopy was the most important factor in the development of atopy.
There was a trend to increasing degrees of sensitisation with allergen exposure in infancy, and an inverse relationship between early exposure to Der p I and the age of first wheeze in atopic children (p<0.001). The environmental influences of parental smoking, breast feeding or proven viral infections in infancy had no effect. An additional study was undertaken to investigate the atopic status and current allergen exposure in a group of 86 children admitted to hospital with attacks of asthma.
University of Southampton
1994
Sporik, Richard Bernard
(1994)
The natural history of allergic diseases in children : a prospective clinical, immunological and environmental study.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
To investigate the natural history of allergic disease in children and to identify potential risk factor, a cohort of 67 babies (35 boys) at risk of developing atopic disorders were followed prospectively for 11 years. On the basis of allergen skin testing 35 were atopic (skin weal >4mm), its expression increased with age. The yearly period prevalence of hay fever increased with age, that of eczema declined, while that for wheeze showed a bimodal distribution with a peak prior to 2 and a gradual increase thereafter. These conditions were heterogeneous, with atopy being associated with their persistence. The children with asthma (current wheeze and bronchial hyperresponsiveness to histamine) at 11 were sensitised to indoor allergens, predominantly those from the house dust mite (Der p I) (p<0.001). At age 11, parental atopy was the most important factor in the development of atopy.
There was a trend to increasing degrees of sensitisation with allergen exposure in infancy, and an inverse relationship between early exposure to Der p I and the age of first wheeze in atopic children (p<0.001). The environmental influences of parental smoking, breast feeding or proven viral infections in infancy had no effect. An additional study was undertaken to investigate the atopic status and current allergen exposure in a group of 86 children admitted to hospital with attacks of asthma.
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Published date: 1994
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Local EPrints ID: 458421
URI: http://eprints.soton.ac.uk/id/eprint/458421
PURE UUID: 2966c1da-3c2a-4646-8f8b-c667e727307e
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Date deposited: 04 Jul 2022 16:48
Last modified: 04 Jul 2022 16:48
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Author:
Richard Bernard Sporik
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