Measurements of urea kinetics in non-pregnant and pregnant women
Measurements of urea kinetics in non-pregnant and pregnant women
The measurement of urea kinetics may be used to characterize the adequacy of dietary protein, in terms of quality and quantity. Urea kinetics were measured using 15N15N-Urea isotope in healthy non-pregnant and pregnant women by both the Prime/Intermittent dose method (ID) and the Single dose method (SD). Thirteen different non-pregnant women were measured on a series of occasions; with longitudinal ID and SD measurements made on two groups of pregnant women containing thirteen and nine women respectively.
No significant differences were identified in urea kinetics with either level of nitrogen intake, stage of menstrual cycle or method of measurement. There was however an effect of using an oral contraceptive pill on Day 12 of the menstrual cycle where values for Eu/P, T/P and P/I were 52.6%, 47.4% and 120% compared to 68.7%, 31.3% and 103% in the women not using a contraceptive pill.
The ID measurements in pregnant women demonstrated significant differences in nitrogen metabolism. Urea excretion, salvage and excretion expressed relative to production varied at 16, 24 and 32 weeks pregnant where the values of Eu/P were 69%, 55%, 70% and for T/P 31%, 45% and 30%. These data demonstrate modifications in the internal ordering of nitrogen metabolism associated with the laying down of foetal tissue in the second trimester of pregnancy.
The SD measurements in pregnancy showed similar results providing further evidence that this method may be used to make non-invasive, free-living measurements in the community - a very important consideration for future research.
It may be concluded that there is the need to determine nitrogen balance, protein turnover and the rate of salvage of urea nitrogen for a complete description of the changes in whole body protein metabolism which take place with pregnancy or the menstrual cycle.
University of Southampton
McClelland, Irene Sarah Margaret
13005cc7-2cf4-456b-a7a4-67904cc8f337
1994
McClelland, Irene Sarah Margaret
13005cc7-2cf4-456b-a7a4-67904cc8f337
McClelland, Irene Sarah Margaret
(1994)
Measurements of urea kinetics in non-pregnant and pregnant women.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The measurement of urea kinetics may be used to characterize the adequacy of dietary protein, in terms of quality and quantity. Urea kinetics were measured using 15N15N-Urea isotope in healthy non-pregnant and pregnant women by both the Prime/Intermittent dose method (ID) and the Single dose method (SD). Thirteen different non-pregnant women were measured on a series of occasions; with longitudinal ID and SD measurements made on two groups of pregnant women containing thirteen and nine women respectively.
No significant differences were identified in urea kinetics with either level of nitrogen intake, stage of menstrual cycle or method of measurement. There was however an effect of using an oral contraceptive pill on Day 12 of the menstrual cycle where values for Eu/P, T/P and P/I were 52.6%, 47.4% and 120% compared to 68.7%, 31.3% and 103% in the women not using a contraceptive pill.
The ID measurements in pregnant women demonstrated significant differences in nitrogen metabolism. Urea excretion, salvage and excretion expressed relative to production varied at 16, 24 and 32 weeks pregnant where the values of Eu/P were 69%, 55%, 70% and for T/P 31%, 45% and 30%. These data demonstrate modifications in the internal ordering of nitrogen metabolism associated with the laying down of foetal tissue in the second trimester of pregnancy.
The SD measurements in pregnancy showed similar results providing further evidence that this method may be used to make non-invasive, free-living measurements in the community - a very important consideration for future research.
It may be concluded that there is the need to determine nitrogen balance, protein turnover and the rate of salvage of urea nitrogen for a complete description of the changes in whole body protein metabolism which take place with pregnancy or the menstrual cycle.
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Published date: 1994
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Local EPrints ID: 458556
URI: http://eprints.soton.ac.uk/id/eprint/458556
PURE UUID: 02c2fa7e-f965-4f29-8980-8bc5a092bea2
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Date deposited: 04 Jul 2022 16:51
Last modified: 16 Mar 2024 18:23
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Author:
Irene Sarah Margaret McClelland
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