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The synthesis of novel nucleoside phosphate triesters as potential antiviral agents

The synthesis of novel nucleoside phosphate triesters as potential antiviral agents
The synthesis of novel nucleoside phosphate triesters as potential antiviral agents

5-Phosphate triesters were derived from the nucleosides 882C (1), acyclovir (2), 5'-hydroxyethoxymethyl-9-[2-amino-6-dimethylaminopurine] (3) and 5'-hydroxyethoxymethyl-9-[2-amino-6-cyclopropylamino-purine] (4). These compounds and novel synthetic intermediates were fully characterised by analytical and spectroscopic methods.

All of the novel products were tested against herpes simplex virus (HSV) 2, human immunodeficiency virus (HIV) 1, varicella-zoster virus (VZV), human cytomegalovirus (HCMV) and influenza virus A. Some of these compounds exhibited biological activity against HCMV, VZV, and/or influenza virus A.

University of Southampton
Perry, Alex
ef57d213-8928-4345-908a-a60ecbc2d166
Perry, Alex
ef57d213-8928-4345-908a-a60ecbc2d166

Perry, Alex (1996) The synthesis of novel nucleoside phosphate triesters as potential antiviral agents. University of Southampton, Doctoral Thesis.

Record type: Thesis (Doctoral)

Abstract

5-Phosphate triesters were derived from the nucleosides 882C (1), acyclovir (2), 5'-hydroxyethoxymethyl-9-[2-amino-6-dimethylaminopurine] (3) and 5'-hydroxyethoxymethyl-9-[2-amino-6-cyclopropylamino-purine] (4). These compounds and novel synthetic intermediates were fully characterised by analytical and spectroscopic methods.

All of the novel products were tested against herpes simplex virus (HSV) 2, human immunodeficiency virus (HIV) 1, varicella-zoster virus (VZV), human cytomegalovirus (HCMV) and influenza virus A. Some of these compounds exhibited biological activity against HCMV, VZV, and/or influenza virus A.

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More information

Published date: 1996
Learn more about Chemistry research

Identifiers

Local EPrints ID: 459388
URI: http://eprints.soton.ac.uk/id/eprint/459388
PURE UUID: 85b5c7d8-8787-4ce8-8132-ec794be5c0e9

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Date deposited: 04 Jul 2022 17:09
Last modified: 23 Jul 2022 00:30

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Contributors

Author: Alex Perry

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