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The effect of carbon dioxide on snail neurons

The effect of carbon dioxide on snail neurons
The effect of carbon dioxide on snail neurons

The effects of changes in pCOg, pOg, and pH have been investigated in the neurons of the isolated brain of the & nail, He1ix aspersa, using intracellular electrodes. Anoxia depolarised the membrane of all the cells tested and increased their firing frequency; oxygen reversed this. A few cells were hyperpolarised by levels of pO^ above normal. Small increases in j^iOg produced a response similar to that induced by anoxia; large increases in pCOg produced a more acute depolarisation and decreased both the frequency and the overshoot of the spikes, and this was not a result of the depolarisation. It is suggested that CO^ acts by decreasing the menbrane permeability to and/or Cl" as an increase in membrane resistance was measured. Decreasing the external pH produced some depolarisation but was less potent than solutions of COg. Some cells responded to increased pCOg with rhythmic activity and this may be relevant to the control of respiratory movements. These cells showed cyclic changes in their membrane permeability coherent with the rhythmic pattern of their activity.

University of Southampton
Mathews, Richard William
Mathews, Richard William

Mathews, Richard William (1968) The effect of carbon dioxide on snail neurons. University of Southampton, Doctoral Thesis.

Record type: Thesis (Doctoral)

Abstract

The effects of changes in pCOg, pOg, and pH have been investigated in the neurons of the isolated brain of the & nail, He1ix aspersa, using intracellular electrodes. Anoxia depolarised the membrane of all the cells tested and increased their firing frequency; oxygen reversed this. A few cells were hyperpolarised by levels of pO^ above normal. Small increases in j^iOg produced a response similar to that induced by anoxia; large increases in pCOg produced a more acute depolarisation and decreased both the frequency and the overshoot of the spikes, and this was not a result of the depolarisation. It is suggested that CO^ acts by decreasing the menbrane permeability to and/or Cl" as an increase in membrane resistance was measured. Decreasing the external pH produced some depolarisation but was less potent than solutions of COg. Some cells responded to increased pCOg with rhythmic activity and this may be relevant to the control of respiratory movements. These cells showed cyclic changes in their membrane permeability coherent with the rhythmic pattern of their activity.

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Published date: 1968

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Local EPrints ID: 459672
URI: http://eprints.soton.ac.uk/id/eprint/459672
PURE UUID: 53b23b36-491b-474a-9211-3be631d55c78

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Date deposited: 04 Jul 2022 17:16
Last modified: 04 Jul 2022 18:10

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Contributors

Author: Richard William Mathews

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