The assessment of intra-pulmonary deposition of aerosols using multi-modality imaging
The assessment of intra-pulmonary deposition of aerosols using multi-modality imaging
Single Photon Emission Computed Tomography (SPECT) is now accepted as one method of providing three-dimensional (3-D) images. Using SPECT, we have reconstructed 3-D images incorporating an attenuation correction technique utilising aligned Magnetic Resonance Imaging (MRI) of the thorax.
The use of SPECT and combined MRI was applied to clinical studies in healthy and mild asthmatic subjects with the hypothesis being that the such a 3-D imaging system offers more information on the fate of inhaled aerosols than a 2-D system. Deposition of nebulised radio-aerosols (99mTc labelled human serum albumin) of 1.8μm MMD (Optimist, Medic-Aid) and 6.8μm MMD (Inspiron Bard) was assessed in 12 healthy subjects and 10 subjects with mild asthma, using a cross-over design. Aerosol deposition was assessed by dividing the three-dimensional reconstruction of the lung into ten concentric shells, each having a specific fractional distance between the centre and the periphery of the lung. Using this 'shell analysis', percentage deposition and activity concentrations, per shell, were evaluated. SPECT/MRI was found to be more sensitive than planar scintigraphy in determining the greater central deposition for the larger aerosol. Individual patterns of deposition could also be described. SPECT/MRI further allowed the deposition within the right lung to be described as polar plots. It was established that some of the indices inferring small airway obstruction were associated with decreased peripheral deposition of the fine aerosol as assessed by SPECT/MRI but not by planar imaging. The multi-modality imaging technique of combined SPECT/MRI offers greater and superior information to that of planar imaging - when applied to therapeutic, aerosol deposition studies and whilst more technically complex - is recommended for future studies.
University of Southampton
Conway, Joyce Helen
f50d231a-bfc3-475f-b59d-8942e284ba8a
1996
Conway, Joyce Helen
f50d231a-bfc3-475f-b59d-8942e284ba8a
Conway, Joyce Helen
(1996)
The assessment of intra-pulmonary deposition of aerosols using multi-modality imaging.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
Single Photon Emission Computed Tomography (SPECT) is now accepted as one method of providing three-dimensional (3-D) images. Using SPECT, we have reconstructed 3-D images incorporating an attenuation correction technique utilising aligned Magnetic Resonance Imaging (MRI) of the thorax.
The use of SPECT and combined MRI was applied to clinical studies in healthy and mild asthmatic subjects with the hypothesis being that the such a 3-D imaging system offers more information on the fate of inhaled aerosols than a 2-D system. Deposition of nebulised radio-aerosols (99mTc labelled human serum albumin) of 1.8μm MMD (Optimist, Medic-Aid) and 6.8μm MMD (Inspiron Bard) was assessed in 12 healthy subjects and 10 subjects with mild asthma, using a cross-over design. Aerosol deposition was assessed by dividing the three-dimensional reconstruction of the lung into ten concentric shells, each having a specific fractional distance between the centre and the periphery of the lung. Using this 'shell analysis', percentage deposition and activity concentrations, per shell, were evaluated. SPECT/MRI was found to be more sensitive than planar scintigraphy in determining the greater central deposition for the larger aerosol. Individual patterns of deposition could also be described. SPECT/MRI further allowed the deposition within the right lung to be described as polar plots. It was established that some of the indices inferring small airway obstruction were associated with decreased peripheral deposition of the fine aerosol as assessed by SPECT/MRI but not by planar imaging. The multi-modality imaging technique of combined SPECT/MRI offers greater and superior information to that of planar imaging - when applied to therapeutic, aerosol deposition studies and whilst more technically complex - is recommended for future studies.
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Published date: 1996
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Local EPrints ID: 459820
URI: http://eprints.soton.ac.uk/id/eprint/459820
PURE UUID: 6ab44f03-0c68-40c1-8584-d334accffa9d
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Date deposited: 04 Jul 2022 17:19
Last modified: 23 Jul 2022 00:31
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Author:
Joyce Helen Conway
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