The University of Southampton
University of Southampton Institutional Repository

Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood

Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, Torrens, Christopher, Newman, James P., Poston, Lucilla, Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2007) Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood Proceedings of the National Academy of Sciences, 104, (22), pp. 9529-9533. (doi:10.1073/pnas.0610373104).

Record type: Article


The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit to the fetus, but the long-term effects of these adaptations may prove detrimental if nutrition in postnatal life does not match that predicted by the fetus on the basis of its prenatal environment. We tested this predictive adaptive response hypothesis with respect to CV function in sheep. We observed that a mismatch between pre- and postnatal nutrient environments induced an altered CV function in adult male sheep that was not seen when environments were similar. Sheep that received postnatal undernutrition alone had altered growth, CV function, and basal hypothalamo–pituitary–adrenal axis activity in adulthood. Prenatal undernutrition induced greater weight gain by weaning compared with the prenatal control diet, which may provide a reserve in the face of a predicted poor diet in later life. In an adequate postnatal nutrient environment (i.e., relatively mismatched), these offspring exhibited cardiac hypertrophy and altered CV function in adulthood. These data support the concept that adult CV function can be determined by developmental responses to intrauterine nutrition made in expectation of the postnatal nutritional environment, and that if these predictions are not met, the adult may be maladapted and at greater risk of CV disease. Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies.

Full text not available from this repository.

More information

Published date: 4 May 2007
Keywords: fetal development, postnatal development, predictive adaptive response
Organisations: Dev Origins of Health & Disease


Local EPrints ID: 45988
ISSN: 0027-8424
PURE UUID: bb1c181a-897f-4605-916f-3fe2bd5d0b0e
ORCID for Kirsten R. Poore: ORCID iD
ORCID for Lucy R. Green: ORCID iD

Catalogue record

Date deposited: 08 May 2007
Last modified: 17 Jul 2017 15:09

Export record



Author: Jane K. Cleal
Author: Julian P. Boullin
Author: Omar Khan
Author: Ryan Chau
Author: Oliver Hambidge
Author: James P. Newman
Author: Lucilla Poston
Author: David E. Noakes
Author: Mark A. Hanson
Author: Lucy R. Green ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.