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Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood

Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood
Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit to the fetus, but the long-term effects of these adaptations may prove detrimental if nutrition in postnatal life does not match that predicted by the fetus on the basis of its prenatal environment. We tested this predictive adaptive response hypothesis with respect to CV function in sheep. We observed that a mismatch between pre- and postnatal nutrient environments induced an altered CV function in adult male sheep that was not seen when environments were similar. Sheep that received postnatal undernutrition alone had altered growth, CV function, and basal hypothalamo–pituitary–adrenal axis activity in adulthood. Prenatal undernutrition induced greater weight gain by weaning compared with the prenatal control diet, which may provide a reserve in the face of a predicted poor diet in later life. In an adequate postnatal nutrient environment (i.e., relatively mismatched), these offspring exhibited cardiac hypertrophy and altered CV function in adulthood. These data support the concept that adult CV function can be determined by developmental responses to intrauterine nutrition made in expectation of the postnatal nutritional environment, and that if these predictions are not met, the adult may be maladapted and at greater risk of CV disease. Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies.
fetal development, postnatal development, predictive adaptive response
0027-8424
9529-9533
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, Kirsten R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Boullin, Julian P.
735364c5-fe0d-45fa-bdfc-5f16e132ff80
Khan, Omar
b0170e98-eb6b-44b9-b3b5-d9dd70b67850
Chau, Ryan
7197f680-6698-4384-91db-43bffb25b0a2
Hambidge, Oliver
355e4ce7-b2af-47dc-852a-6b4d3f27c556
Torrens, Christopher
15a35713-0651-4249-8227-5901e2cfcd22
Newman, James P.
66b510f1-a2cd-4f9f-a1a7-53aaccc644f5
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Cleal, Jane K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Poore, Kirsten R.
b9529ba3-6432-4935-b8fd-6e382f11f0ad
Boullin, Julian P.
735364c5-fe0d-45fa-bdfc-5f16e132ff80
Khan, Omar
b0170e98-eb6b-44b9-b3b5-d9dd70b67850
Chau, Ryan
7197f680-6698-4384-91db-43bffb25b0a2
Hambidge, Oliver
355e4ce7-b2af-47dc-852a-6b4d3f27c556
Torrens, Christopher
15a35713-0651-4249-8227-5901e2cfcd22
Newman, James P.
66b510f1-a2cd-4f9f-a1a7-53aaccc644f5
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5

Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, Torrens, Christopher, Newman, James P., Poston, Lucilla, Noakes, David E., Hanson, Mark A. and Green, Lucy R. (2007) Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proceedings of the National Academy of Sciences, 104 (22), 9529-9533. (doi:10.1073/pnas.0610373104).

Record type: Article

Abstract

The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit to the fetus, but the long-term effects of these adaptations may prove detrimental if nutrition in postnatal life does not match that predicted by the fetus on the basis of its prenatal environment. We tested this predictive adaptive response hypothesis with respect to CV function in sheep. We observed that a mismatch between pre- and postnatal nutrient environments induced an altered CV function in adult male sheep that was not seen when environments were similar. Sheep that received postnatal undernutrition alone had altered growth, CV function, and basal hypothalamo–pituitary–adrenal axis activity in adulthood. Prenatal undernutrition induced greater weight gain by weaning compared with the prenatal control diet, which may provide a reserve in the face of a predicted poor diet in later life. In an adequate postnatal nutrient environment (i.e., relatively mismatched), these offspring exhibited cardiac hypertrophy and altered CV function in adulthood. These data support the concept that adult CV function can be determined by developmental responses to intrauterine nutrition made in expectation of the postnatal nutritional environment, and that if these predictions are not met, the adult may be maladapted and at greater risk of CV disease. Our findings have substantial implications for devising strategies to reduce the impact of a mismatch in nutrition levels in humans undergoing rapid socio-economic transitions in both developing and developed societies.

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More information

Published date: 4 May 2007
Keywords: fetal development, postnatal development, predictive adaptive response
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 45988
URI: https://eprints.soton.ac.uk/id/eprint/45988
ISSN: 0027-8424
PURE UUID: bb1c181a-897f-4605-916f-3fe2bd5d0b0e
ORCID for Jane K. Cleal: ORCID iD orcid.org/0000-0001-7978-4327
ORCID for Kirsten R. Poore: ORCID iD orcid.org/0000-0002-1455-0615
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for Lucy R. Green: ORCID iD orcid.org/0000-0001-7423-9696

Catalogue record

Date deposited: 08 May 2007
Last modified: 31 Jul 2019 00:46

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Contributors

Author: Jane K. Cleal ORCID iD
Author: Julian P. Boullin
Author: Omar Khan
Author: Ryan Chau
Author: Oliver Hambidge
Author: James P. Newman
Author: Lucilla Poston
Author: David E. Noakes
Author: Mark A. Hanson ORCID iD
Author: Lucy R. Green ORCID iD

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