The effects and side effects of regular inhaled corticosteroids on episodes of viral associated wheeze in school age children
The effects and side effects of regular inhaled corticosteroids on episodes of viral associated wheeze in school age children
The aims of the study were to determine the effects and side effects of regular inhaled corticosteroids on episodes of viral associated wheeze in school age children.
The study was randomised, double blind, placebo controlled, comparing the effect of inhaled beclomethasone dipropionate (BDP) 200 μg or placebo twice daily via a diskhaler. The children completed a daily symptom diary on upper (URT) and lower respiratory (LRT) symptoms, and each morning and evening recorded the highest of three peak expiratory flow (PEF) measurements.
The children who received BDP had significantly higher FEV1 and methacholine PD20 during the treatment period compared to placebo. Although the children who received BDP had significantly lower mean percentage of days with URT symptoms compared to placebo, there were no significant differences in frequency, severity or duration of URT episodes. There were no significant differences in percentage of days with LRT symptoms; in frequency, severity or duration of LRT episodes; in % average diurnal of variation in PEF or coefficient of variation of the morning PEF; or in frequency, severity or duration of PEF episodes during the treatment period between the BDP and placebo treated children.
Mean growth was significantly decreased during the treatment period in the BDP treated group compared to the placebo group, 0.79 v 1.14 mm/week. At the end of the treatment period the children receiving BDP had grown 1cm less than the children receiving placebo, and there was no catch up growth once treatment was discontinued.
It is concluded that regular BDP 200 μg twice daily offers little therapeutic benefit in school age children with episodic wheeze, and results in significant growth impairment. In this group of children with episodic wheeze the effects of inhaled corticosteroids were outweighed by their side effects.
University of Southampton
1996
Doull, Iolo John Manley
(1996)
The effects and side effects of regular inhaled corticosteroids on episodes of viral associated wheeze in school age children.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The aims of the study were to determine the effects and side effects of regular inhaled corticosteroids on episodes of viral associated wheeze in school age children.
The study was randomised, double blind, placebo controlled, comparing the effect of inhaled beclomethasone dipropionate (BDP) 200 μg or placebo twice daily via a diskhaler. The children completed a daily symptom diary on upper (URT) and lower respiratory (LRT) symptoms, and each morning and evening recorded the highest of three peak expiratory flow (PEF) measurements.
The children who received BDP had significantly higher FEV1 and methacholine PD20 during the treatment period compared to placebo. Although the children who received BDP had significantly lower mean percentage of days with URT symptoms compared to placebo, there were no significant differences in frequency, severity or duration of URT episodes. There were no significant differences in percentage of days with LRT symptoms; in frequency, severity or duration of LRT episodes; in % average diurnal of variation in PEF or coefficient of variation of the morning PEF; or in frequency, severity or duration of PEF episodes during the treatment period between the BDP and placebo treated children.
Mean growth was significantly decreased during the treatment period in the BDP treated group compared to the placebo group, 0.79 v 1.14 mm/week. At the end of the treatment period the children receiving BDP had grown 1cm less than the children receiving placebo, and there was no catch up growth once treatment was discontinued.
It is concluded that regular BDP 200 μg twice daily offers little therapeutic benefit in school age children with episodic wheeze, and results in significant growth impairment. In this group of children with episodic wheeze the effects of inhaled corticosteroids were outweighed by their side effects.
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Published date: 1996
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Local EPrints ID: 460141
URI: http://eprints.soton.ac.uk/id/eprint/460141
PURE UUID: 0af9d620-aff7-4bf5-8bbf-d2b6f6e10b4d
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Date deposited: 04 Jul 2022 18:00
Last modified: 04 Jul 2022 18:00
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Author:
Iolo John Manley Doull
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