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Isoxsuprine ; a possible interaction with cholinergic neurones in the rat brain

Isoxsuprine ; a possible interaction with cholinergic neurones in the rat brain
Isoxsuprine ; a possible interaction with cholinergic neurones in the rat brain
The origins of the cholinergic innervation of the rat neocortex were studied by means of neurotoxic amino acid lesions and neurochemical analysis. A crude topographical pattern of projections from the cholinergic perikarya within the magnocellular nuclei of the basal forebrain to the allocortex were determined. The more rostrally located cells of the medial septal complex project to the hippocampus,
whilst the more caudally located neurones of the nucleus basalis project to the ipsilateral parietal cortex and the amygdala. No evidence for a cholinergic projection to the cortex from the medial septum was found. The neurochemical specificity and neuroanatomical selectivity of ibotenic acid lesions of the ventral globus pallidus were studied using both neurochemical and histological techniques. Similarities between the degeneration produced by these lesions and the neurodegenerative disorder Alzheimer's dementia are discussed, in respect of a possible 'animal model' for this disorder.
The effects of isoxsuprine, a drug reported to alleviate the symptoms of senile dementia, on the uptake of oxygen in vitro, and [3H] 2-deoxyglucose in vivo into discrete areas of rat brain were studied. In vivo pretreatment with isoxsuprine was found to stimulate oxygen uptake into rat brain cortex slices. No significant effect on [3H] 2-deoxyglucose uptake could be determined. The effects of isoxsuprine pretreatment oncholine acetyltransferase activity and high affinity choline uptake were also studied.
These results are again discussed in terms of the currently available pharmacotherapy for Alzheimer's dementia.
University of Southampton
Davies, Stephen Whitworth
ca0aece7-611a-44d7-9edf-f3a6da243fa7
Davies, Stephen Whitworth
ca0aece7-611a-44d7-9edf-f3a6da243fa7
Horn, N.M.
39a5dc8d-0319-4cf1-8c9c-76841ef1dc4f

Davies, Stephen Whitworth (1983) Isoxsuprine ; a possible interaction with cholinergic neurones in the rat brain. University of Southampton, Doctoral Thesis, 225pp.

Record type: Thesis (Doctoral)

Abstract

The origins of the cholinergic innervation of the rat neocortex were studied by means of neurotoxic amino acid lesions and neurochemical analysis. A crude topographical pattern of projections from the cholinergic perikarya within the magnocellular nuclei of the basal forebrain to the allocortex were determined. The more rostrally located cells of the medial septal complex project to the hippocampus,
whilst the more caudally located neurones of the nucleus basalis project to the ipsilateral parietal cortex and the amygdala. No evidence for a cholinergic projection to the cortex from the medial septum was found. The neurochemical specificity and neuroanatomical selectivity of ibotenic acid lesions of the ventral globus pallidus were studied using both neurochemical and histological techniques. Similarities between the degeneration produced by these lesions and the neurodegenerative disorder Alzheimer's dementia are discussed, in respect of a possible 'animal model' for this disorder.
The effects of isoxsuprine, a drug reported to alleviate the symptoms of senile dementia, on the uptake of oxygen in vitro, and [3H] 2-deoxyglucose in vivo into discrete areas of rat brain were studied. In vivo pretreatment with isoxsuprine was found to stimulate oxygen uptake into rat brain cortex slices. No significant effect on [3H] 2-deoxyglucose uptake could be determined. The effects of isoxsuprine pretreatment oncholine acetyltransferase activity and high affinity choline uptake were also studied.
These results are again discussed in terms of the currently available pharmacotherapy for Alzheimer's dementia.

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Published date: 1983

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Local EPrints ID: 460311
URI: http://eprints.soton.ac.uk/id/eprint/460311
PURE UUID: 8e382e42-2860-4a73-85ca-214b43d7cdc9

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Date deposited: 04 Jul 2022 18:18
Last modified: 03 Jun 2024 17:14

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Contributors

Author: Stephen Whitworth Davies
Thesis advisor: N.M. Horn

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