The prevalences and relationships between respiratory symptoms, bronchial responsiveness to methacholine and atopy among 7 and 11 year old school children in an urban population in southern England
The prevalences and relationships between respiratory symptoms, bronchial responsiveness to methacholine and atopy among 7 and 11 year old school children in an urban population in southern England
A respiratory questionnaire was designed for completion by parents and used to study 2,503 seven and eleven year old Southampton school children. Broncial provocation testing with methacholine and skin allergen testing to 3 common allergens was performend on 332 of the same children. The overall prevalences of wheeze and shortness of breath in the current year were 12.1% and 8.5% respectively. The symptoms of wheeze and breathlessness occurred more commonly in boys, but there were only small difference between the sexes with respect to cough. There was a marked fall in the prevalence of cough beteen 7 and 11 year olds but not associated change in the prevalence of wheeze. When controlling for the other respiratory symptoms, only wheeze was significantly related to parental asthma. Wheeze was strongly related to bronchial responsiveness and was the only symptom related to atopy. However, wheeze was only related to bronchial responsiveness in the presence of atopy and to atopy in the presence of bronchial responsiveness to ≤6.4μmol of methacholine (BRM). Other symptoms were unrelated to either phenomenon when controlling for wheeze. The prevalence of the combination of wheeze + atopy + BRM increased between 7 years and 11 years but there were decreases in the prevalences of cough and wheeze in the absence of atopy or BRM. Wheeze + BRM + atopy represents a distinct entity which is likely to be related to the clinical diagnosis of asthma.
University of Southampton
1990
Clifford, Rollo David
(1990)
The prevalences and relationships between respiratory symptoms, bronchial responsiveness to methacholine and atopy among 7 and 11 year old school children in an urban population in southern England.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
A respiratory questionnaire was designed for completion by parents and used to study 2,503 seven and eleven year old Southampton school children. Broncial provocation testing with methacholine and skin allergen testing to 3 common allergens was performend on 332 of the same children. The overall prevalences of wheeze and shortness of breath in the current year were 12.1% and 8.5% respectively. The symptoms of wheeze and breathlessness occurred more commonly in boys, but there were only small difference between the sexes with respect to cough. There was a marked fall in the prevalence of cough beteen 7 and 11 year olds but not associated change in the prevalence of wheeze. When controlling for the other respiratory symptoms, only wheeze was significantly related to parental asthma. Wheeze was strongly related to bronchial responsiveness and was the only symptom related to atopy. However, wheeze was only related to bronchial responsiveness in the presence of atopy and to atopy in the presence of bronchial responsiveness to ≤6.4μmol of methacholine (BRM). Other symptoms were unrelated to either phenomenon when controlling for wheeze. The prevalence of the combination of wheeze + atopy + BRM increased between 7 years and 11 years but there were decreases in the prevalences of cough and wheeze in the absence of atopy or BRM. Wheeze + BRM + atopy represents a distinct entity which is likely to be related to the clinical diagnosis of asthma.
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Published date: 1990
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Local EPrints ID: 460476
URI: http://eprints.soton.ac.uk/id/eprint/460476
PURE UUID: 31540b09-e431-4b72-86ae-bdf1d378798f
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Date deposited: 04 Jul 2022 18:23
Last modified: 04 Jul 2022 18:23
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Author:
Rollo David Clifford
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