Influence of diet and disease on human intestinal microflora, colonic function and faecal energy
Influence of diet and disease on human intestinal microflora, colonic function and faecal energy
The availability of energy from the diet is determined by the extent of digestion and absorption and the metabolic activity of the colonic microflora. Attempts to measure the energy available to the body through digestion and absorption presume that all of faecal material is derived solely from dietary residue. Two other components may also contribute to the material present in faeces; endogenous secretions and cellular debris and colonic bacterial microflora. The studies presented in this thesis have demonstrated the normal limits of faecal energy in healthy adults and during growth and development in childhood. The magnitude of faecal energy could be modified with alterations in dietary non-starch polysaccharides (NSP) intakes and with maldigestion and/or malabsorption in the disease cystic fibrosis (CF). It has been possible to isolate faecal bacteria and demonstrate that a major component of the energy, lipid and nitrogen within the stool may be derived from the colonic bacteria. The metabolic activity of the colonic microflora could be modified with alterations in dietary NSP intakes and the availability of maldigested and/or malabsorbed dietary residue and endogenous losses in CF. Colonic fermentation may determine the extent to which energy may be salvaged and made available to the host in the form of short chain fatty acids. These findings demonstrate the importance of determining the origins of energy within the stool and the impact of colonic bacterial function in relation to the maintenance of energy balance with diets rich in fermentable substrate and in extensive maldigestion and/or malabsorption.
University of Southampton
Murphy, Jane Louise
22fed869-0b98-47c2-a841-285bfae5bcad
1991
Murphy, Jane Louise
22fed869-0b98-47c2-a841-285bfae5bcad
Murphy, Jane Louise
(1991)
Influence of diet and disease on human intestinal microflora, colonic function and faecal energy.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The availability of energy from the diet is determined by the extent of digestion and absorption and the metabolic activity of the colonic microflora. Attempts to measure the energy available to the body through digestion and absorption presume that all of faecal material is derived solely from dietary residue. Two other components may also contribute to the material present in faeces; endogenous secretions and cellular debris and colonic bacterial microflora. The studies presented in this thesis have demonstrated the normal limits of faecal energy in healthy adults and during growth and development in childhood. The magnitude of faecal energy could be modified with alterations in dietary non-starch polysaccharides (NSP) intakes and with maldigestion and/or malabsorption in the disease cystic fibrosis (CF). It has been possible to isolate faecal bacteria and demonstrate that a major component of the energy, lipid and nitrogen within the stool may be derived from the colonic bacteria. The metabolic activity of the colonic microflora could be modified with alterations in dietary NSP intakes and the availability of maldigested and/or malabsorbed dietary residue and endogenous losses in CF. Colonic fermentation may determine the extent to which energy may be salvaged and made available to the host in the form of short chain fatty acids. These findings demonstrate the importance of determining the origins of energy within the stool and the impact of colonic bacterial function in relation to the maintenance of energy balance with diets rich in fermentable substrate and in extensive maldigestion and/or malabsorption.
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Published date: 1991
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Local EPrints ID: 460653
URI: http://eprints.soton.ac.uk/id/eprint/460653
PURE UUID: ce503af3-d21d-44bd-be6e-d5a43e8896e5
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Date deposited: 04 Jul 2022 18:26
Last modified: 16 Mar 2024 18:40
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Author:
Jane Louise Murphy
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