The prevalence of diabetic nephropathy : a study based on proteinuria and albuminuria in a defined diabetic population
The prevalence of diabetic nephropathy : a study based on proteinuria and albuminuria in a defined diabetic population
During a surveillance programme, all the known diabetics (917) were identified from a study population of 90,660 representing all the patients registered with 40 general practitioners. A single observer reviewed 842 (92% ) of these diabetics. Proteinuria (0.3 g/l or more) was detected using Albustix in 57 cases (6.8%), but in 9 this was in association with an urinary tract infection. There was a significant relationship between the presence of retinopathy and proteinuria. Both systolic and diastolic blood pressure levels were significantly higher in diabetics with proteinuria than those without. Serum creatinine was greater than 150 umol/l in 29 (3.8%) of the 768 diabetics in whom it was measured. However, proteinuria was only found in 7 of the diabetics with impaired renal function. Urinary albumin was measured by a micro-ELISA technique on random urine samples and timed overnight urine collections. Laboratory reference ranges were determined for the daytime random albumin/creatinine ratio (RA/C) and the overnight albumin excretion rate (AER) using 114 non-diabetic controls. Age, systolic and diastolic blood pressure levels were significantly correlated with AER, but not RA/C, in the controls, although following a multiple regression analysis only systolic blood pressure remained significant. A raised RA/C was found in 38% (204 fo 532) of the diabetics and a raised AER in 30% (133 of 450) of the diabetics. AER was significantly correlated with blood glucose, HbAl, systolic blood pressure, diastolic blood pressure, body mass index, male sex, presence of retinopathy and current smoking habit. A stepwise multiple regression found only blood glucose, body mass index, current smoking habit and systolic blood pressure to be significant, and together accounted for 10.5% of the variation in AER. (D71794/87)
University of Southampton
Gatling, Wendy
43ab7653-f74c-4b25-bd27-db8b84807a5b
1986
Gatling, Wendy
43ab7653-f74c-4b25-bd27-db8b84807a5b
Gatling, Wendy
(1986)
The prevalence of diabetic nephropathy : a study based on proteinuria and albuminuria in a defined diabetic population.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
During a surveillance programme, all the known diabetics (917) were identified from a study population of 90,660 representing all the patients registered with 40 general practitioners. A single observer reviewed 842 (92% ) of these diabetics. Proteinuria (0.3 g/l or more) was detected using Albustix in 57 cases (6.8%), but in 9 this was in association with an urinary tract infection. There was a significant relationship between the presence of retinopathy and proteinuria. Both systolic and diastolic blood pressure levels were significantly higher in diabetics with proteinuria than those without. Serum creatinine was greater than 150 umol/l in 29 (3.8%) of the 768 diabetics in whom it was measured. However, proteinuria was only found in 7 of the diabetics with impaired renal function. Urinary albumin was measured by a micro-ELISA technique on random urine samples and timed overnight urine collections. Laboratory reference ranges were determined for the daytime random albumin/creatinine ratio (RA/C) and the overnight albumin excretion rate (AER) using 114 non-diabetic controls. Age, systolic and diastolic blood pressure levels were significantly correlated with AER, but not RA/C, in the controls, although following a multiple regression analysis only systolic blood pressure remained significant. A raised RA/C was found in 38% (204 fo 532) of the diabetics and a raised AER in 30% (133 of 450) of the diabetics. AER was significantly correlated with blood glucose, HbAl, systolic blood pressure, diastolic blood pressure, body mass index, male sex, presence of retinopathy and current smoking habit. A stepwise multiple regression found only blood glucose, body mass index, current smoking habit and systolic blood pressure to be significant, and together accounted for 10.5% of the variation in AER. (D71794/87)
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Published date: 1986
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Local EPrints ID: 460676
URI: http://eprints.soton.ac.uk/id/eprint/460676
PURE UUID: 9d033106-f982-4693-9cc0-d7d05249d4fb
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Date deposited: 04 Jul 2022 18:27
Last modified: 23 Jul 2022 00:58
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Author:
Wendy Gatling
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