Evaluation of plasminogen function in health and disease
Evaluation of plasminogen function in health and disease
The expanding knowledge and importance of the fibrinolytic system necessitate a proper evaluation of plasminogen function in various physiological and pathologic conditions. Inherited abnormalities of plasminogen molecule resulting in abnormal function and impaired fibrinolysis with increased tendency to thrombosis have been reported by several authors. To examine the possible existence of acquired plasminogen functional defects, plasminogen and alpha 2 anti-plasmin levels were monitored in different groups of patients. an assay system for measurement of plasmnogen activation in whole plasma using chromogenic substrate S-2251 was assessed and developed. This assay system was used to evaluate plasminogen function in normal adults, full term newborn infants, pregnant women, patients with liver cirrhosis, deep vein thrombosis and those in the post-operative period. Plasma Plasminogen levels, using both immunological and functional assays, were found to be lower in newborn infants and patients with liver cirrhosis and higher in pregnancy, post-operative period and patients with post operative deep vein thrombosis than that of normal adults. Plasminogen activation kinetics in plasma showed normal activation patterns, using urokinase and streptokinase, in full term newborn infants, pregnancy, post-operative patients and patients with deep vein thrombosis. The possible existence of acquired plasminogen functional defects, in these conditions, was excluded. However, the rate of plasmin generation was found to be low in few patients with liver disease. This represented a departure from the normal functional behaviour of plasminogen species and suggests a possible existence of a plasminogen functional defect in liver cirrhosis.
University of Southampton
Al-Hilali, Mahir Mohamad Ali
1990
Al-Hilali, Mahir Mohamad Ali
Al-Hilali, Mahir Mohamad Ali
(1990)
Evaluation of plasminogen function in health and disease.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The expanding knowledge and importance of the fibrinolytic system necessitate a proper evaluation of plasminogen function in various physiological and pathologic conditions. Inherited abnormalities of plasminogen molecule resulting in abnormal function and impaired fibrinolysis with increased tendency to thrombosis have been reported by several authors. To examine the possible existence of acquired plasminogen functional defects, plasminogen and alpha 2 anti-plasmin levels were monitored in different groups of patients. an assay system for measurement of plasmnogen activation in whole plasma using chromogenic substrate S-2251 was assessed and developed. This assay system was used to evaluate plasminogen function in normal adults, full term newborn infants, pregnant women, patients with liver cirrhosis, deep vein thrombosis and those in the post-operative period. Plasma Plasminogen levels, using both immunological and functional assays, were found to be lower in newborn infants and patients with liver cirrhosis and higher in pregnancy, post-operative period and patients with post operative deep vein thrombosis than that of normal adults. Plasminogen activation kinetics in plasma showed normal activation patterns, using urokinase and streptokinase, in full term newborn infants, pregnancy, post-operative patients and patients with deep vein thrombosis. The possible existence of acquired plasminogen functional defects, in these conditions, was excluded. However, the rate of plasmin generation was found to be low in few patients with liver disease. This represented a departure from the normal functional behaviour of plasminogen species and suggests a possible existence of a plasminogen functional defect in liver cirrhosis.
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Published date: 1990
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Local EPrints ID: 461151
URI: http://eprints.soton.ac.uk/id/eprint/461151
PURE UUID: 7d0623f4-b0ae-4f57-83bc-cf4b39c44db8
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Date deposited: 04 Jul 2022 18:36
Last modified: 04 Jul 2022 18:36
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Author:
Mahir Mohamad Ali Al-Hilali
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