A longitudinal study of the natural history of airways disease in children with cough and wheeze : the effect of atopy on symptoms, peak flow variability, and bronchial responsiveness
A longitudinal study of the natural history of airways disease in children with cough and wheeze : the effect of atopy on symptoms, peak flow variability, and bronchial responsiveness
The aims of this study were: to determine whether children with cough as a sole symptom represent a different disease group from those with wheeze, to examine the role of atopy in determining the pattern of airways disease in children, and to examine the prevalence, severity and variability over time of bronchial responsiveness and its relationship to symptoms and the presence of atopy. A respiratory questionnaire was sent to 3,698 children aged 7 and 8 years. The response rate was 90%. Those children reporting either cough alone (12.8%) or wheeze with or without cough (14.8%) were randomised, and a sample was invited to attend for skin testing. 192 children, half with cough, half with wheeze, half of each group being atopic, were selected to enter the longitudinal study. We conclude, that, with regard to the parameters of respiratory morbidity exmained in this study, children with cough differ significantly from those with wheeze, and may represent a different population. Children with atopy demonstrated a different pattern of airways disease compared to those without, regardless of symptom type. In particular, atopy was associated with more chronic symptoms. Asthma appears to be a heterogeneous disease. BHR was by no means inevitable amongst these symptomatic children, although it was more common in those with atopy and with wheeze. Bronchial responsiveness in individuals demonstrates considerable variation over time. In addition we found that the number of young children suffering from significant respiratory symptoms is appreciably greater than the number diagnosed as having asthma, and that much of the respiratory morbidity occurring in discrete episodes, lung function is normal between episodes.
University of Southampton
1992
Clough, Joanne Barbara
(1992)
A longitudinal study of the natural history of airways disease in children with cough and wheeze : the effect of atopy on symptoms, peak flow variability, and bronchial responsiveness.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The aims of this study were: to determine whether children with cough as a sole symptom represent a different disease group from those with wheeze, to examine the role of atopy in determining the pattern of airways disease in children, and to examine the prevalence, severity and variability over time of bronchial responsiveness and its relationship to symptoms and the presence of atopy. A respiratory questionnaire was sent to 3,698 children aged 7 and 8 years. The response rate was 90%. Those children reporting either cough alone (12.8%) or wheeze with or without cough (14.8%) were randomised, and a sample was invited to attend for skin testing. 192 children, half with cough, half with wheeze, half of each group being atopic, were selected to enter the longitudinal study. We conclude, that, with regard to the parameters of respiratory morbidity exmained in this study, children with cough differ significantly from those with wheeze, and may represent a different population. Children with atopy demonstrated a different pattern of airways disease compared to those without, regardless of symptom type. In particular, atopy was associated with more chronic symptoms. Asthma appears to be a heterogeneous disease. BHR was by no means inevitable amongst these symptomatic children, although it was more common in those with atopy and with wheeze. Bronchial responsiveness in individuals demonstrates considerable variation over time. In addition we found that the number of young children suffering from significant respiratory symptoms is appreciably greater than the number diagnosed as having asthma, and that much of the respiratory morbidity occurring in discrete episodes, lung function is normal between episodes.
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Published date: 1992
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Local EPrints ID: 461693
URI: http://eprints.soton.ac.uk/id/eprint/461693
PURE UUID: 50c90636-8a47-411a-8ce1-cacc413c4b02
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Date deposited: 04 Jul 2022 18:52
Last modified: 04 Jul 2022 18:52
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Author:
Joanne Barbara Clough
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