Lymphocyte marker studies in malignant lymphomas
Lymphocyte marker studies in malignant lymphomas
Lymphocyte populations in Hodgkin's and non Hodgkin's lymphomas were analysed with a range. of lymphocyte markers. Control (reactive) lymph nodes and spleens, studied as a baseline for comparison with lymphoma populations, contained equal proportions of T and B lymphocytes although in small, unstimulated modes the proportion of T cells was higher.Lymphocyte markers confirmed an origin from B lymphocytes for 20 out of23 non Hodgkin's lymphoma cases studied; two cases had a histiocyticorigin and one was unclassifiable. The intensity of the monotypic surface immunoglobulin staining (by direct immunofluorescence) and the presence of cytoplasmic immunoglobulin confirmed the concept that the spectrum of morphology exhibited by non-Hodgkin's lymphomas is a reflection of maturity (Lakes and Collins, 1975; Cerard Marchant e±a11g7tt).Fb and C3 receptors were present on most, but not all, B lymphoma cells but there was no correlation between the presence and strength of these receptors and B cell maturity. T lymphocytes were present is all lymphoma tissues, except one. The higher incidence of T cells in nodular cases, which are prognostically more benign than diffuse types, was considered as evidence of a cellular immune reaction.Malignant Reed-Sternberg cells and their mononuclear variants (Hodgkin's cells) in Hodgkin's disease were shown to have marker characteristics of B lymphocytes. Compared with controls involved lymph nodes contained elevated proportions of T lymphocytes (p<0.001). T lymphocytes (many of which showed features of activation) were seen to adhere to the surface of Hodgkin's cells which may reflect specific reactivity of T cells to the tumour cells. Hodgkin's tissues also showed B cell reactivity, most marked in spleens. The possibility that this was related to autoantibody production was suggested by evidence of immunoglobulin coated T cells in Hodgkin's tissues and anti-T cell activity. in Hodgkin's sera. These findings are discussed in terms of the 'lymphocyte war' implicated in the aetiology of Hodgkin's disease (Smithers, 1967).
University of Southampton
1977
Payne, Sandra Vivian
(1977)
Lymphocyte marker studies in malignant lymphomas.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
Lymphocyte populations in Hodgkin's and non Hodgkin's lymphomas were analysed with a range. of lymphocyte markers. Control (reactive) lymph nodes and spleens, studied as a baseline for comparison with lymphoma populations, contained equal proportions of T and B lymphocytes although in small, unstimulated modes the proportion of T cells was higher.Lymphocyte markers confirmed an origin from B lymphocytes for 20 out of23 non Hodgkin's lymphoma cases studied; two cases had a histiocyticorigin and one was unclassifiable. The intensity of the monotypic surface immunoglobulin staining (by direct immunofluorescence) and the presence of cytoplasmic immunoglobulin confirmed the concept that the spectrum of morphology exhibited by non-Hodgkin's lymphomas is a reflection of maturity (Lakes and Collins, 1975; Cerard Marchant e±a11g7tt).Fb and C3 receptors were present on most, but not all, B lymphoma cells but there was no correlation between the presence and strength of these receptors and B cell maturity. T lymphocytes were present is all lymphoma tissues, except one. The higher incidence of T cells in nodular cases, which are prognostically more benign than diffuse types, was considered as evidence of a cellular immune reaction.Malignant Reed-Sternberg cells and their mononuclear variants (Hodgkin's cells) in Hodgkin's disease were shown to have marker characteristics of B lymphocytes. Compared with controls involved lymph nodes contained elevated proportions of T lymphocytes (p<0.001). T lymphocytes (many of which showed features of activation) were seen to adhere to the surface of Hodgkin's cells which may reflect specific reactivity of T cells to the tumour cells. Hodgkin's tissues also showed B cell reactivity, most marked in spleens. The possibility that this was related to autoantibody production was suggested by evidence of immunoglobulin coated T cells in Hodgkin's tissues and anti-T cell activity. in Hodgkin's sera. These findings are discussed in terms of the 'lymphocyte war' implicated in the aetiology of Hodgkin's disease (Smithers, 1967).
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Published date: 1977
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Local EPrints ID: 462364
URI: http://eprints.soton.ac.uk/id/eprint/462364
PURE UUID: f05deda0-82bf-4faa-9250-bf4072058ee0
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Date deposited: 04 Jul 2022 19:06
Last modified: 04 Jul 2022 19:06
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Author:
Sandra Vivian Payne
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