Clinical, genetic and histopathological features of skin cysts
Clinical, genetic and histopathological features of skin cysts
In a personally conducted study of 137 families with skin cysts, it was possible to distinguish four distinct clinical and histological types of 9 cyst. These are dermoid cysts, epidermoid cysts, trichilemmal cysts andsteatocystoma multiplex. Dermoid cysts arise from skin displaced at the time of embryonic skin closure. They are present from birth, situated mainly on the head and neck and have a lining made up of normal skin and its appendages. There is no evidence that they are genetically determined. The other three types of cyst occur after puberty and each is inherited as an autosomal dominant trait. Epidermoid cysts have a lining very similar to normal epidermis, are usually solitary and occur on the face and trunk. They arise from the infundibulum of the hair follicle or from the eccrine sweat duct and retain a connection to the overlying skin. Because of this, they frequently become secondarily infected. Trichilemmakl cysts arise from the external root sheath in the region of 3 the follicular isthmus. Most occur on the scalp and since there is no connection with the overlying skin, they do not become infected. Steatocystoma multiplex is the least common variety of cyst. They are probably hamartomas and contain skin appendages in their walls. Multiple small, symmetrically situated cysts occur on the trunk and face in males and in the major flexures in females. There is a more severe variety in which hugh numbers of cysts, many of them secondarily infected, occur all over the body in association with pachyonychia congenita. It is important to differentiate the cysts from each other for two reasons. Firstly, only trichhilemmal cysts are easily removed. Secondly, epidermoid cysts, when they occur before puberty may be an important first sign of familial polyposis coli. Their recognition can lead to early diagnosis of the bowel problem and prevention of large bowel malignancy. It is therefore no longer acceptable to call all cysts sebaceous cysts Iand to regard them as unimportant.
University of Southampton
1980
Leppard, Barbara Joan
(1980)
Clinical, genetic and histopathological features of skin cysts.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
In a personally conducted study of 137 families with skin cysts, it was possible to distinguish four distinct clinical and histological types of 9 cyst. These are dermoid cysts, epidermoid cysts, trichilemmal cysts andsteatocystoma multiplex. Dermoid cysts arise from skin displaced at the time of embryonic skin closure. They are present from birth, situated mainly on the head and neck and have a lining made up of normal skin and its appendages. There is no evidence that they are genetically determined. The other three types of cyst occur after puberty and each is inherited as an autosomal dominant trait. Epidermoid cysts have a lining very similar to normal epidermis, are usually solitary and occur on the face and trunk. They arise from the infundibulum of the hair follicle or from the eccrine sweat duct and retain a connection to the overlying skin. Because of this, they frequently become secondarily infected. Trichilemmakl cysts arise from the external root sheath in the region of 3 the follicular isthmus. Most occur on the scalp and since there is no connection with the overlying skin, they do not become infected. Steatocystoma multiplex is the least common variety of cyst. They are probably hamartomas and contain skin appendages in their walls. Multiple small, symmetrically situated cysts occur on the trunk and face in males and in the major flexures in females. There is a more severe variety in which hugh numbers of cysts, many of them secondarily infected, occur all over the body in association with pachyonychia congenita. It is important to differentiate the cysts from each other for two reasons. Firstly, only trichhilemmal cysts are easily removed. Secondly, epidermoid cysts, when they occur before puberty may be an important first sign of familial polyposis coli. Their recognition can lead to early diagnosis of the bowel problem and prevention of large bowel malignancy. It is therefore no longer acceptable to call all cysts sebaceous cysts Iand to regard them as unimportant.
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Published date: 1980
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Local EPrints ID: 462741
URI: http://eprints.soton.ac.uk/id/eprint/462741
PURE UUID: 8770f6a5-68eb-4c9d-9cf8-b2b10879ee59
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Date deposited: 04 Jul 2022 19:51
Last modified: 04 Jul 2022 19:51
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Author:
Barbara Joan Leppard
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