Coronary heart disease, diabetes, serum lipid concentrations and lung function in relation to fetal growth in South India
Coronary heart disease, diabetes, serum lipid concentrations and lung function in relation to fetal growth in South India
Coronary heart disease, non-insulin dependent diabetes, disturbances in lipid metabolism and reduced lung function, as well as intra-uterine growth retardation are common in India. To test the 'fetal origins hypothesis' in India we traced 517 men and women who were born in a mission hospital in Mysore, South India, still live in the city and whose size at birth had been recorded. We measured the prevalence of coronary heart disease and diabetes, serum lipid concentrations and lung function among them and related it to their size at birth.
Low birthweight, short length and small head circumference at birth were associated with a raised prevalence of coronary heart disease, independent of known coronary risk factors. High rates were also found in those whose mothers had a low body weight during pregnancy; the highest prevalence was associated with a combination of low birthweight and low maternal weight. In this population two types of babies developed abnormal adult glucose/insulin metabolism: Fatter babies born to heavier mothers, and low birthweight babies born to small mothers. Reduced serum HDL cholesterol concentrations were associated with low birthweight in both sexes; in men but not in women, low birthweight was also related to raised serum triglyceride levels. Total and LDL cholesterol concentrations were associated with small head circumference at birth in both sexes. Low birthweight and small head circumference were related to reduced lung function, independent of smoking and social class.
Consistent with the 'fetal origins hypothesis' we have shown that coronary heart disease, diabetes, alterations in lipid metabolism and reduced lung function are associated with fetal growth retardation in urban India, suggesting that the pathogenesis is influenced by events in utero. Our data further reveal that the physique and health of mothers contribute to the pathogenesis of disease in the offspring, plausibly by inducing changes in fetal growth pattern.
University of Southampton
Stein, Claudia Elizabeth
96a47980-5d70-4940-978c-d5789f7cf96c
1997
Stein, Claudia Elizabeth
96a47980-5d70-4940-978c-d5789f7cf96c
Stein, Claudia Elizabeth
(1997)
Coronary heart disease, diabetes, serum lipid concentrations and lung function in relation to fetal growth in South India.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
Coronary heart disease, non-insulin dependent diabetes, disturbances in lipid metabolism and reduced lung function, as well as intra-uterine growth retardation are common in India. To test the 'fetal origins hypothesis' in India we traced 517 men and women who were born in a mission hospital in Mysore, South India, still live in the city and whose size at birth had been recorded. We measured the prevalence of coronary heart disease and diabetes, serum lipid concentrations and lung function among them and related it to their size at birth.
Low birthweight, short length and small head circumference at birth were associated with a raised prevalence of coronary heart disease, independent of known coronary risk factors. High rates were also found in those whose mothers had a low body weight during pregnancy; the highest prevalence was associated with a combination of low birthweight and low maternal weight. In this population two types of babies developed abnormal adult glucose/insulin metabolism: Fatter babies born to heavier mothers, and low birthweight babies born to small mothers. Reduced serum HDL cholesterol concentrations were associated with low birthweight in both sexes; in men but not in women, low birthweight was also related to raised serum triglyceride levels. Total and LDL cholesterol concentrations were associated with small head circumference at birth in both sexes. Low birthweight and small head circumference were related to reduced lung function, independent of smoking and social class.
Consistent with the 'fetal origins hypothesis' we have shown that coronary heart disease, diabetes, alterations in lipid metabolism and reduced lung function are associated with fetal growth retardation in urban India, suggesting that the pathogenesis is influenced by events in utero. Our data further reveal that the physique and health of mothers contribute to the pathogenesis of disease in the offspring, plausibly by inducing changes in fetal growth pattern.
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Published date: 1997
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Local EPrints ID: 462985
URI: http://eprints.soton.ac.uk/id/eprint/462985
PURE UUID: 10559734-bc24-477b-a0e1-c148a07467d5
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Date deposited: 04 Jul 2022 20:34
Last modified: 23 Jul 2022 01:09
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Author:
Claudia Elizabeth Stein
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