The influence of HLA DR on soluble CD23 secretion and serum soluble CD23 as a marker of immune dysregulation in human disease
The influence of HLA DR on soluble CD23 secretion and serum soluble CD23 as a marker of immune dysregulation in human disease
The work presented in this thesis initially established the stability of serum sCD23 in vitro and the clinical (infection, renal/hepatic function and drugs) and demographic factors (age and sex) which determined the levels of this protein in serum. Subsequent work was the first to record increased levels of serum sCD23 in many of the systemic and organ specific autoimmune diseases. The source of serum sCD23 as being of predominantly B cell was also discovered by recording the serum levels in patients with varying numbers of normal and abnormal B cells. The value of serum sCD23 in determining the overall balance of cellular and humoral immunity (regulated by the Th1/Th2 cytokines) in a given disease was proposed. This was based on finding elevated serum levels in the autoimmune diseases associated with hypergammaglobulinaemia and autoantibody formation and low levels in those conditions with clinical and histological features of exaggerated cellular immunity such as Chrohn's and coeliac disease. This notion was further suggested by finding low levels in tuberculoid leprosy and higher levels in lepromatous leprosy which is consistent with increased Th1 and Th2 type immunity in these conditions. Using this simple model the state of cellular and humoral immunity in patients with increasing stages of HIV infection and established insulin dependent diabetes was reported. With additional cytokine data further work on serum sCD23 was reported on the factors responsible for autoimmunity and lymphoma formation in chronic hepatitis C virus infection and the peripheral anergy in sarcoidosis. Both of these were the first such investigations on these specific subjects in these conditions. This was also the case in the investigation of cellular and humoral immunity in patients with primary sclerosing cholangitis and coeliac disease.
University of Southampton
Bansal, Amolak Singh
5c832715-a759-4391-b1e2-7766e0b95a65
1998
Bansal, Amolak Singh
5c832715-a759-4391-b1e2-7766e0b95a65
Bansal, Amolak Singh
(1998)
The influence of HLA DR on soluble CD23 secretion and serum soluble CD23 as a marker of immune dysregulation in human disease.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The work presented in this thesis initially established the stability of serum sCD23 in vitro and the clinical (infection, renal/hepatic function and drugs) and demographic factors (age and sex) which determined the levels of this protein in serum. Subsequent work was the first to record increased levels of serum sCD23 in many of the systemic and organ specific autoimmune diseases. The source of serum sCD23 as being of predominantly B cell was also discovered by recording the serum levels in patients with varying numbers of normal and abnormal B cells. The value of serum sCD23 in determining the overall balance of cellular and humoral immunity (regulated by the Th1/Th2 cytokines) in a given disease was proposed. This was based on finding elevated serum levels in the autoimmune diseases associated with hypergammaglobulinaemia and autoantibody formation and low levels in those conditions with clinical and histological features of exaggerated cellular immunity such as Chrohn's and coeliac disease. This notion was further suggested by finding low levels in tuberculoid leprosy and higher levels in lepromatous leprosy which is consistent with increased Th1 and Th2 type immunity in these conditions. Using this simple model the state of cellular and humoral immunity in patients with increasing stages of HIV infection and established insulin dependent diabetes was reported. With additional cytokine data further work on serum sCD23 was reported on the factors responsible for autoimmunity and lymphoma formation in chronic hepatitis C virus infection and the peripheral anergy in sarcoidosis. Both of these were the first such investigations on these specific subjects in these conditions. This was also the case in the investigation of cellular and humoral immunity in patients with primary sclerosing cholangitis and coeliac disease.
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Published date: 1998
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Local EPrints ID: 463509
URI: http://eprints.soton.ac.uk/id/eprint/463509
PURE UUID: 2d027a48-405d-43fe-928a-01abd88280b0
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Date deposited: 04 Jul 2022 20:52
Last modified: 23 Jul 2022 01:09
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Author:
Amolak Singh Bansal
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