Functional nano-particles derived from dendrimer derivatisation and self-assembly
Functional nano-particles derived from dendrimer derivatisation and self-assembly
A series of dendritic species based on the PAMAM dendrimers synthetic methodology of D. A. Tomalia have been prepared. These compounds were then functionalised with sugar residues using three separate strategies that have produced dendrimer "sugar balls" that have more surface functional groups than have been prepared previously. These macromolecular species were prepared by the direct combination of the dendrimer with glucose, with glucopryanosyl bromide to generate charged species and finally with glucose isothiocyanates.
Once these dendritic species had been prepared they were examined by photon correlation spectroscopy and transmission electron microscopy to determine their size. The particles were also used in viscosity measurements, to investigate the effect of different solvents on the particle size, and to evaluate the occurrence of intermolecular interactions between the dendritic particles and sugar molecules present in solution.
The final part of this project involved the preparation of a new type of drug delivery system. The particles that we have prepared have a central dendrimer core to which a transmembrane glycoprotein is attached by an intermolecular ionic interaction. A phospholipid membrane is then formed that encapsulates the system. These particles have been termed neovirosomes.
University of Southampton
1998
Probert, John Michael
(1998)
Functional nano-particles derived from dendrimer derivatisation and self-assembly.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
A series of dendritic species based on the PAMAM dendrimers synthetic methodology of D. A. Tomalia have been prepared. These compounds were then functionalised with sugar residues using three separate strategies that have produced dendrimer "sugar balls" that have more surface functional groups than have been prepared previously. These macromolecular species were prepared by the direct combination of the dendrimer with glucose, with glucopryanosyl bromide to generate charged species and finally with glucose isothiocyanates.
Once these dendritic species had been prepared they were examined by photon correlation spectroscopy and transmission electron microscopy to determine their size. The particles were also used in viscosity measurements, to investigate the effect of different solvents on the particle size, and to evaluate the occurrence of intermolecular interactions between the dendritic particles and sugar molecules present in solution.
The final part of this project involved the preparation of a new type of drug delivery system. The particles that we have prepared have a central dendrimer core to which a transmembrane glycoprotein is attached by an intermolecular ionic interaction. A phospholipid membrane is then formed that encapsulates the system. These particles have been termed neovirosomes.
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Published date: 1998
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Local EPrints ID: 463551
URI: http://eprints.soton.ac.uk/id/eprint/463551
PURE UUID: e745261f-2c9b-44bc-9ddc-b620c83ac372
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Date deposited: 04 Jul 2022 20:53
Last modified: 04 Jul 2022 20:53
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Author:
John Michael Probert
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