The synthesis and application of novel chiral transition metal complexes
The synthesis and application of novel chiral transition metal complexes
The synthesis of a variety of novel chiral annulated cyclopentadienyl ligands and the preparation of novel chiral metallocene complexes of zirconium, titanium and rhodium is described. The novel complexes are evaluated as catalysts in asymmetric reductions and carbon-carbon bond-forming reactions. Chapter 1 provides an introduction to the research, outlining the methodology and stating the aims of the project. A literature review of chiral annulated cyclopentadienyl ligands and of the use of Group IV metallocenes in asymmetric catalysis is presented. Chapter 2 deals with the synthesis of Group IV metallocenes derived from camphor. Chapter 3 introduces the use of a double-Michael addition reaction to access a variety of elaborate chiral (but racemic) cyclopentadienyl ligands, and their diastereoselective complexation to titanium and zirconium is investigated. In Chapter 4 an enantioselective double-Michael addition reaction is developed, to provide a novel cyclopentadienyl ligand derived from carvone. Titanium and zirconium complexes of the carvone-derived cyclopentadienyl ligand are prepared, and the resulting metallocenes are evaluated in asymmetric catalysis. Chapter 5 describes the synthesis of novel rhodium cyclopentadienyl complexes and their application to catalytic asymmetric hydrogenations. Full experimental details are given in Chapter 6, including complete characterisation of all novel compounds.
University of Southampton
1999
Green, Simon Michael
(1999)
The synthesis and application of novel chiral transition metal complexes.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The synthesis of a variety of novel chiral annulated cyclopentadienyl ligands and the preparation of novel chiral metallocene complexes of zirconium, titanium and rhodium is described. The novel complexes are evaluated as catalysts in asymmetric reductions and carbon-carbon bond-forming reactions. Chapter 1 provides an introduction to the research, outlining the methodology and stating the aims of the project. A literature review of chiral annulated cyclopentadienyl ligands and of the use of Group IV metallocenes in asymmetric catalysis is presented. Chapter 2 deals with the synthesis of Group IV metallocenes derived from camphor. Chapter 3 introduces the use of a double-Michael addition reaction to access a variety of elaborate chiral (but racemic) cyclopentadienyl ligands, and their diastereoselective complexation to titanium and zirconium is investigated. In Chapter 4 an enantioselective double-Michael addition reaction is developed, to provide a novel cyclopentadienyl ligand derived from carvone. Titanium and zirconium complexes of the carvone-derived cyclopentadienyl ligand are prepared, and the resulting metallocenes are evaluated in asymmetric catalysis. Chapter 5 describes the synthesis of novel rhodium cyclopentadienyl complexes and their application to catalytic asymmetric hydrogenations. Full experimental details are given in Chapter 6, including complete characterisation of all novel compounds.
This record has no associated files available for download.
More information
Published date: 1999
Identifiers
Local EPrints ID: 463582
URI: http://eprints.soton.ac.uk/id/eprint/463582
PURE UUID: e978bd22-a70f-45ba-bb50-2780e944d795
Catalogue record
Date deposited: 04 Jul 2022 20:54
Last modified: 04 Jul 2022 20:54
Export record
Contributors
Author:
Simon Michael Green
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics