The association of upper respiratory tract viral infection and asthma in adults
The association of upper respiratory tract viral infection and asthma in adults
This thesis describes experiments to determine the relationship between upper respiratory tract (URT) viral infection and exacerbations of asthma.
Chapter 2 describes the development of a multiplex RT-PCR for the detection of the parainfluenza viruses. This method was shown to be as sensitive as tissue culture when applied to cultured virus and nasal aspirates taken from children with symptomatic respiratory tract infections.
Chapter 3 describes a 3 month study aimed at determining whether asthmatic individuals wee more susceptible to HRV infection than non-asthmatic individuals. A previously validated RT-PCR for rhinovirus (HRV) was used to test nasal aspirates taken every 2 weeks from each member of 76 couples in whom one partner was asthmatic and the other non-atopic, non-asthmatic. There was no difference in HRV infection rates between the asthmatic and non-asthmatic volunteers.
Chapter 4 describes a study of 139 atopic asthmatics who were followed for 15 months with the aim of determining the relationship between URT viral infection and exacerbations of asthma. Nasal aspirates were taken during the development of upper or lower respiratory tract symptoms or at times of falls in PEF. Upper respiratory tract viruses were detected using RT-PCR. There were a total of 215 reports from which samples were available for analysis. An URT virus was found in association with 58% of reported episodes lower respiratory tract episodes. The commonest virus was rhinovirus accounting for 63% of viruses. An URT virus was found in only 9.2% of samples taken when the volunteer has been asymptomatic for 2 weeks. It was therefore concluded that URT viruses are important precipitants of exacerbations of asthma in adult asthmatics. These results suggest that URTviruses have an important role in the morbidity associated with asthma and that further research should concentrate on elucidating possible mechanisms of virus induced exacerbations of asthma.
University of Southampton
1999
Corne, Jonathan
(1999)
The association of upper respiratory tract viral infection and asthma in adults.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
This thesis describes experiments to determine the relationship between upper respiratory tract (URT) viral infection and exacerbations of asthma.
Chapter 2 describes the development of a multiplex RT-PCR for the detection of the parainfluenza viruses. This method was shown to be as sensitive as tissue culture when applied to cultured virus and nasal aspirates taken from children with symptomatic respiratory tract infections.
Chapter 3 describes a 3 month study aimed at determining whether asthmatic individuals wee more susceptible to HRV infection than non-asthmatic individuals. A previously validated RT-PCR for rhinovirus (HRV) was used to test nasal aspirates taken every 2 weeks from each member of 76 couples in whom one partner was asthmatic and the other non-atopic, non-asthmatic. There was no difference in HRV infection rates between the asthmatic and non-asthmatic volunteers.
Chapter 4 describes a study of 139 atopic asthmatics who were followed for 15 months with the aim of determining the relationship between URT viral infection and exacerbations of asthma. Nasal aspirates were taken during the development of upper or lower respiratory tract symptoms or at times of falls in PEF. Upper respiratory tract viruses were detected using RT-PCR. There were a total of 215 reports from which samples were available for analysis. An URT virus was found in association with 58% of reported episodes lower respiratory tract episodes. The commonest virus was rhinovirus accounting for 63% of viruses. An URT virus was found in only 9.2% of samples taken when the volunteer has been asymptomatic for 2 weeks. It was therefore concluded that URT viruses are important precipitants of exacerbations of asthma in adult asthmatics. These results suggest that URTviruses have an important role in the morbidity associated with asthma and that further research should concentrate on elucidating possible mechanisms of virus induced exacerbations of asthma.
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Published date: 1999
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Local EPrints ID: 463650
URI: http://eprints.soton.ac.uk/id/eprint/463650
PURE UUID: 7efae328-7f2f-4f37-91fc-38e29a352ec6
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Date deposited: 04 Jul 2022 20:54
Last modified: 04 Jul 2022 20:54
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Author:
Jonathan Corne
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