The histopathology of primary gastrointestinal lymphoma
The histopathology of primary gastrointestinal lymphoma
In an investigation of 75 cases of primary gastrointestinal lymphoma 22 cases were identified which had occurred in association with coeliac disease. The clinical and histopathological features of these cases were studied in detail using routine histology, lu sections of resin embedded tissue, electron microscopy, histochemistry and immunoperoxidase techniques. This study revealed that the same characteristic variety of lymphoma had occurred in each case, with the malignant cells exhibiting clear histiocytic features. The tumours were frequently disseminated in other lymphoreticular tissues and the pattern of dissemination closely resembled that described in malignant histiocytosis. In the course of the study it became clear that this disorder, which is best termed malignant histiocytosis of the intestine (MIII), is closely related to ulcerative jejunitis and probably accounts for most cases of this poorly understood complication of coeliac disease. The histopathology of a further 48 cases of primary gastrointestinal lymphoma was studied with emphasis on immunoperoxidase techniques and lU sections of resin embedded tissue resulting in a classification of 70 cases from the Wessex region of England. Lymphocyte derived tumours accounted for 44% of the lymphomas while 47% of the cases were derived from histiocytes. Of the histiocyte derived tumours 31Z were examples of MHI and 16Z were histiocytic lymphomas (HL). HL is not associated with coeliac disease, forms solid tumour masses and involves regional lymph nodes in a pattern similar to lymphocyte derived tumours. Immunohistochemically the cells of MHI and HL both contained polytypic Ig, predominantly IgG, and lysozyme but al-antitrypsin was present exclusively in MHI. The immunohistochemical techniques developed in this study were applied to 5 cases of Mediterranean lymphoma including 3 cases of proven a chain disease. The results showed that it is possible to diagnose a chain disease in routine paraffin sections and that not all cases of Mediterranean lymphoma are associated with a chain disease. Immunoperoxidase techniques also allow easy identification of the different stages of a chain disease which could be important in management.
University of Southampton
1979
Isaacson, Peter
(1979)
The histopathology of primary gastrointestinal lymphoma.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
In an investigation of 75 cases of primary gastrointestinal lymphoma 22 cases were identified which had occurred in association with coeliac disease. The clinical and histopathological features of these cases were studied in detail using routine histology, lu sections of resin embedded tissue, electron microscopy, histochemistry and immunoperoxidase techniques. This study revealed that the same characteristic variety of lymphoma had occurred in each case, with the malignant cells exhibiting clear histiocytic features. The tumours were frequently disseminated in other lymphoreticular tissues and the pattern of dissemination closely resembled that described in malignant histiocytosis. In the course of the study it became clear that this disorder, which is best termed malignant histiocytosis of the intestine (MIII), is closely related to ulcerative jejunitis and probably accounts for most cases of this poorly understood complication of coeliac disease. The histopathology of a further 48 cases of primary gastrointestinal lymphoma was studied with emphasis on immunoperoxidase techniques and lU sections of resin embedded tissue resulting in a classification of 70 cases from the Wessex region of England. Lymphocyte derived tumours accounted for 44% of the lymphomas while 47% of the cases were derived from histiocytes. Of the histiocyte derived tumours 31Z were examples of MHI and 16Z were histiocytic lymphomas (HL). HL is not associated with coeliac disease, forms solid tumour masses and involves regional lymph nodes in a pattern similar to lymphocyte derived tumours. Immunohistochemically the cells of MHI and HL both contained polytypic Ig, predominantly IgG, and lysozyme but al-antitrypsin was present exclusively in MHI. The immunohistochemical techniques developed in this study were applied to 5 cases of Mediterranean lymphoma including 3 cases of proven a chain disease. The results showed that it is possible to diagnose a chain disease in routine paraffin sections and that not all cases of Mediterranean lymphoma are associated with a chain disease. Immunoperoxidase techniques also allow easy identification of the different stages of a chain disease which could be important in management.
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Published date: 1979
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Local EPrints ID: 463803
URI: http://eprints.soton.ac.uk/id/eprint/463803
PURE UUID: be82dd84-47a9-4836-b0ac-087100ae510c
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Date deposited: 04 Jul 2022 20:57
Last modified: 04 Jul 2022 20:57
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Author:
Peter Isaacson
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