The University of Southampton
University of Southampton Institutional Repository

Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material

Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material
Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material
SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.
photoresist, oligonucleotides, immobilization, capillary-electrophoresis, high-aspect-ratio, archip epoxy, mass-spectrometry, peptide-synthesis, protease inhibitors, mems
1520-4766
462-472
Cavalli, Gabriel
37d26614-5388-4c24-b5ad-531715d1ddb7
Banu, Shahanara
5e1caab9-665e-4a17-b582-28a059acdf06
Ranasinghe, Rohan T.
b29fc8b4-2a66-430a-85fa-ff1c9c261f32
Broder, Graham R.
6e8722f8-020d-4df6-85a1-30f2f5fdf419
Martins, Hugo F.P.
d3c0a265-fcd4-4dc7-bdff-6b3cb5642dd6
Neylon, Cameron
697f067b-db25-4c41-9618-28f4b74f73aa
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Roach, Peter L.
ca94060c-4443-482b-af3e-979243488ba9
Cavalli, Gabriel
37d26614-5388-4c24-b5ad-531715d1ddb7
Banu, Shahanara
5e1caab9-665e-4a17-b582-28a059acdf06
Ranasinghe, Rohan T.
b29fc8b4-2a66-430a-85fa-ff1c9c261f32
Broder, Graham R.
6e8722f8-020d-4df6-85a1-30f2f5fdf419
Martins, Hugo F.P.
d3c0a265-fcd4-4dc7-bdff-6b3cb5642dd6
Neylon, Cameron
697f067b-db25-4c41-9618-28f4b74f73aa
Morgan, Hywel
de00d59f-a5a2-48c4-a99a-1d5dd7854174
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Roach, Peter L.
ca94060c-4443-482b-af3e-979243488ba9

Cavalli, Gabriel, Banu, Shahanara, Ranasinghe, Rohan T., Broder, Graham R., Martins, Hugo F.P., Neylon, Cameron, Morgan, Hywel, Bradley, Mark and Roach, Peter L. (2007) Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material. Journal of Combinatorial Chemistry, 9 (3), 462-472. (doi:10.1021/cc060079p).

Record type: Article

Abstract

SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.

Full text not available from this repository.

More information

Published date: 2007
Keywords: photoresist, oligonucleotides, immobilization, capillary-electrophoresis, high-aspect-ratio, archip epoxy, mass-spectrometry, peptide-synthesis, protease inhibitors, mems
Organisations: Chemistry

Identifiers

Local EPrints ID: 46382
URI: https://eprints.soton.ac.uk/id/eprint/46382
ISSN: 1520-4766
PURE UUID: 2d4b5a16-96ae-4703-8c73-c4a9e469361a
ORCID for Hywel Morgan: ORCID iD orcid.org/0000-0003-4850-5676
ORCID for Peter L. Roach: ORCID iD orcid.org/0000-0001-9880-2877

Catalogue record

Date deposited: 27 Jun 2007
Last modified: 29 Aug 2019 00:47

Export record

Altmetrics

Contributors

Author: Gabriel Cavalli
Author: Shahanara Banu
Author: Rohan T. Ranasinghe
Author: Graham R. Broder
Author: Hugo F.P. Martins
Author: Cameron Neylon
Author: Hywel Morgan ORCID iD
Author: Mark Bradley
Author: Peter L. Roach ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×