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Quality of life in pancreatic cancer and chronic pancreatitis

Quality of life in pancreatic cancer and chronic pancreatitis
Quality of life in pancreatic cancer and chronic pancreatitis

A multi-method approach was taken to examine QoL in pancreatic cancer. An in-depth study based upon grounded theory was used to investigate patients' and health professionals' perception of QoL in pancreatic cancer. This study was used to develop a multilingual disease-specific QoL instrument for pancreatic cancer using EORTC guidelines for module development. A prospective longitudinal study was undertaken to assess the reliability, validity and responsiveness to change of the EORTC QLQ-C30 and the disease-specific instrument in patients with pancreatic cancer.

Two hundred and five patients in ten countries were recruited. The grounded theory study demonstrated good agreement of QoL issues between health professionals and patients. However, differences in perception were observed when the context of why QoL issues were important was examined between the two groups. Pancreatic cancer patients' perception of their illness, treatment and care are described. The EORTC pancreatic-specific QoL instrument, the QLQ-PAN26 was produced following multilingual development. A longitudinal study has provided preliminary evidence towards the scale formation, internal consistency, construct validity and responsiveness to change of the EORTC QLQ-C30 and QLQ-PAN26 in pancreatic cancer patients. Baseline QoL scores were not significantly predictive of survival in pancreatic cancer patients with different prognosis. These instruments appear to be valid and reliable assessments of QoL in patients with chronic pancreatitis.

This thesis provides an in-depth account of QoL in pancreatic cancer and chronic pancreatitis. The EORTC QLQ-PAN26 is now being widely used in a number of clinical studies. The use of a multi-method approach to QoL instrument development is reported with critique of the current conceptual and methodological basis of QoL research. This study provides the basis for future research into QoL in pancreatic diseases.

University of Southampton
Fitzsimmons, Deborah
4e282651-162f-48f0-bbf7-190c265279f2
Fitzsimmons, Deborah
4e282651-162f-48f0-bbf7-190c265279f2

Fitzsimmons, Deborah (2000) Quality of life in pancreatic cancer and chronic pancreatitis. University of Southampton, Doctoral Thesis.

Record type: Thesis (Doctoral)

Abstract

A multi-method approach was taken to examine QoL in pancreatic cancer. An in-depth study based upon grounded theory was used to investigate patients' and health professionals' perception of QoL in pancreatic cancer. This study was used to develop a multilingual disease-specific QoL instrument for pancreatic cancer using EORTC guidelines for module development. A prospective longitudinal study was undertaken to assess the reliability, validity and responsiveness to change of the EORTC QLQ-C30 and the disease-specific instrument in patients with pancreatic cancer.

Two hundred and five patients in ten countries were recruited. The grounded theory study demonstrated good agreement of QoL issues between health professionals and patients. However, differences in perception were observed when the context of why QoL issues were important was examined between the two groups. Pancreatic cancer patients' perception of their illness, treatment and care are described. The EORTC pancreatic-specific QoL instrument, the QLQ-PAN26 was produced following multilingual development. A longitudinal study has provided preliminary evidence towards the scale formation, internal consistency, construct validity and responsiveness to change of the EORTC QLQ-C30 and QLQ-PAN26 in pancreatic cancer patients. Baseline QoL scores were not significantly predictive of survival in pancreatic cancer patients with different prognosis. These instruments appear to be valid and reliable assessments of QoL in patients with chronic pancreatitis.

This thesis provides an in-depth account of QoL in pancreatic cancer and chronic pancreatitis. The EORTC QLQ-PAN26 is now being widely used in a number of clinical studies. The use of a multi-method approach to QoL instrument development is reported with critique of the current conceptual and methodological basis of QoL research. This study provides the basis for future research into QoL in pancreatic diseases.

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Published date: 2000

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Local EPrints ID: 464192
URI: http://eprints.soton.ac.uk/id/eprint/464192
PURE UUID: 872fec6f-8a74-4b01-9b93-bd607709ecd5

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Date deposited: 04 Jul 2022 21:30
Last modified: 16 Mar 2024 19:19

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Author: Deborah Fitzsimmons

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