The origin of language-like features in DNA
The origin of language-like features in DNA
Non-coding DNA is known to account for a significant proportion of the genomes of many organisms. The discovery by the use of three statistical tests - the Zipf analysis, the fluctuation analysis and the Shannon entropy - of linguistic features and long-range correlations within non-coding DNA has given rise to the suggestion that this higher-order structure may form the basis of a biological language in non-coding DNA.
This work describes the development of a model to explain the origin of these language-like features in DNA. The model is based on observed genome reshaping processes - namely, transposable element insertion/excision events and point mutations - and involves the repeated duplication of transposable element target sites to build up repetitive blocks of DNA.
This model shows that the observed language-like features can be generated by known genetic rearrangements and therefore suggests that any function of non-coding DNA has been acquired opportunistically, through the use of these language-like features.
University of Southampton
Hurworth, Allan Christopher
42dd2665-4d78-4240-b206-aae0a029c880
2000
Hurworth, Allan Christopher
42dd2665-4d78-4240-b206-aae0a029c880
Hurworth, Allan Christopher
(2000)
The origin of language-like features in DNA.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
Non-coding DNA is known to account for a significant proportion of the genomes of many organisms. The discovery by the use of three statistical tests - the Zipf analysis, the fluctuation analysis and the Shannon entropy - of linguistic features and long-range correlations within non-coding DNA has given rise to the suggestion that this higher-order structure may form the basis of a biological language in non-coding DNA.
This work describes the development of a model to explain the origin of these language-like features in DNA. The model is based on observed genome reshaping processes - namely, transposable element insertion/excision events and point mutations - and involves the repeated duplication of transposable element target sites to build up repetitive blocks of DNA.
This model shows that the observed language-like features can be generated by known genetic rearrangements and therefore suggests that any function of non-coding DNA has been acquired opportunistically, through the use of these language-like features.
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Published date: 2000
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Local EPrints ID: 464309
URI: http://eprints.soton.ac.uk/id/eprint/464309
PURE UUID: 8aa6a119-0114-46cf-bdee-8e7dc4291d98
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Date deposited: 04 Jul 2022 22:03
Last modified: 16 Mar 2024 19:24
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Author:
Allan Christopher Hurworth
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