Development of a 1,3-dithiane linker for the solid phase synthesis of podophyllum lignans

Baldock, Lorraine Elissa (2000) Development of a 1,3-dithiane linker for the solid phase synthesis of podophyllum lignans. University of Southampton, Doctoral Thesis.

Record type: Thesis (Doctoral)

Abstract

In recent years the fight against disease has led the scientists to look for new drugs to fight the infections so prevalent in society today. One such new group of compounds are the podophyllum lignans, which have been shown to have cytotoxic activity against many common cancers. Their main problem are the toxic side effects they exhibit. In order to counteract this scientists have been looking at ways of modifying the peripheral structure of these compounds whilst keeping the central core of the molecule intact. We describe a number of routes to synthesise a 1,3-dithiane linker which will allow the solid phase synthesis of many compounds based upon the podophyllotoxin skeleton. This will allow the rapid determination of the key structural motifs necessary for cytotoxicity, whilst minimising toxic side effects.

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