The Effects of Caffeine Ingestion on the Physiological and Psychological Responses to Hypoglycaemia
The Effects of Caffeine Ingestion on the Physiological and Psychological Responses to Hypoglycaemia
The five studies that constitute this thesis investigated both the impact of caffeine consumption on hypoglycaemic events in free-living patients, as well as the effects of tolerance to the aforementioned responses to hypoglycaemia.
Clinically, caffeine increased the number of symptomatic hypoglycaemic events in free-living patients. This enabled them to take action against hypoglycaemia. This change was not at the expense of increased severe hypoglycaemic events, although the number of such events was small. Pressor responses were preserved in females only but middle cerebral artery blood velocity (VMCA) was most affected in males.
Complete tolerance was not demonstrated in 3 laboratory studies. Following overnight abstention only from caffeine, all responses to hypoglycaemia (2.5 mmolg/1, induced by a hyperinsulinaemic glucose clamp technique ) were augmented after a caffeine challenge compared to placebo. However, due to caffeine's long half-life, these effects continued into the recovery period, as the 'normal' responses to a period of hypoglycaemia were affected, namely no rise in VMCA above baseline, increased time for symptom recovery and restoration of endocrine milieu; in addition possibly slower recovery of cerebral function as measured by P100 visual evoked potentials.
The final study illustrated that caffeine-withdrawal should not be underestimated. Even a small dose of caffeine (that in 2 cans of DIET COKE) ameliorated the symptoms of caffeine withdrawal, with positive effects on mood. In addition VMCA decreased and blood pressure rose following the reintroduction of caffeine.
Thus caffeine alters the responses to hypoglycaemia in both clinical and laboratory studies. Whilst it can negatively affect the recovery period, the ability for it to improve hypoglycaemia awareness proves its potential to be of benefit to patients with type 1 diabetes. Further work is required to investigate its role in the treatment of hypoglycaemia unawareness.
University of Southampton
Watson, Joanne Marie
b2311517-cb26-496a-9b7c-65e82da30243
2000
Watson, Joanne Marie
b2311517-cb26-496a-9b7c-65e82da30243
Watson, Joanne Marie
(2000)
The Effects of Caffeine Ingestion on the Physiological and Psychological Responses to Hypoglycaemia.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The five studies that constitute this thesis investigated both the impact of caffeine consumption on hypoglycaemic events in free-living patients, as well as the effects of tolerance to the aforementioned responses to hypoglycaemia.
Clinically, caffeine increased the number of symptomatic hypoglycaemic events in free-living patients. This enabled them to take action against hypoglycaemia. This change was not at the expense of increased severe hypoglycaemic events, although the number of such events was small. Pressor responses were preserved in females only but middle cerebral artery blood velocity (VMCA) was most affected in males.
Complete tolerance was not demonstrated in 3 laboratory studies. Following overnight abstention only from caffeine, all responses to hypoglycaemia (2.5 mmolg/1, induced by a hyperinsulinaemic glucose clamp technique ) were augmented after a caffeine challenge compared to placebo. However, due to caffeine's long half-life, these effects continued into the recovery period, as the 'normal' responses to a period of hypoglycaemia were affected, namely no rise in VMCA above baseline, increased time for symptom recovery and restoration of endocrine milieu; in addition possibly slower recovery of cerebral function as measured by P100 visual evoked potentials.
The final study illustrated that caffeine-withdrawal should not be underestimated. Even a small dose of caffeine (that in 2 cans of DIET COKE) ameliorated the symptoms of caffeine withdrawal, with positive effects on mood. In addition VMCA decreased and blood pressure rose following the reintroduction of caffeine.
Thus caffeine alters the responses to hypoglycaemia in both clinical and laboratory studies. Whilst it can negatively affect the recovery period, the ability for it to improve hypoglycaemia awareness proves its potential to be of benefit to patients with type 1 diabetes. Further work is required to investigate its role in the treatment of hypoglycaemia unawareness.
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Published date: 2000
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Local EPrints ID: 464509
URI: http://eprints.soton.ac.uk/id/eprint/464509
PURE UUID: be4172a4-e5c4-4b37-8a96-e7e242933c9b
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Date deposited: 04 Jul 2022 23:43
Last modified: 16 Mar 2024 19:34
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Author:
Joanne Marie Watson
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