Towards the combinatorial synthesis of azo-dyes
Towards the combinatorial synthesis of azo-dyes
During this project a variety of novel techniques were investigated for the synthesis of azo-dyes, which could be adapted for use in a combinatorial manner. Initially, this involved the generation and use of diazonium salts supported on ion-exchange resins, and was successfully applied to the synthesis of a 36-member azo-dye library.
Convergent synthesis of a selection of azo-dyes was achieved, using parallel synthetic techniques to prepare the triazine and azo-dye precursors. Microwave synthesis was utilised to produce the final dyes, which were purified by solid-phase extraction. Solution- and solid-phase synthesis of azo-dyes was attempted using a safety-catch linker approach to immobilise the dye intermediates.
Finally, a digital image analysis system was developed to analyse images of resin beads. This system was used to analyse the size-distribution of bead samples and was compared with standard size-analysis methods.
University of Southampton
Merrington, James
17a614a2-69ac-44a9-b208-5417f87ac1e5
2003
Merrington, James
17a614a2-69ac-44a9-b208-5417f87ac1e5
Merrington, James
(2003)
Towards the combinatorial synthesis of azo-dyes.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
During this project a variety of novel techniques were investigated for the synthesis of azo-dyes, which could be adapted for use in a combinatorial manner. Initially, this involved the generation and use of diazonium salts supported on ion-exchange resins, and was successfully applied to the synthesis of a 36-member azo-dye library.
Convergent synthesis of a selection of azo-dyes was achieved, using parallel synthetic techniques to prepare the triazine and azo-dye precursors. Microwave synthesis was utilised to produce the final dyes, which were purified by solid-phase extraction. Solution- and solid-phase synthesis of azo-dyes was attempted using a safety-catch linker approach to immobilise the dye intermediates.
Finally, a digital image analysis system was developed to analyse images of resin beads. This system was used to analyse the size-distribution of bead samples and was compared with standard size-analysis methods.
Text
906252.pdf
- Version of Record
More information
Published date: 2003
Identifiers
Local EPrints ID: 465059
URI: http://eprints.soton.ac.uk/id/eprint/465059
PURE UUID: 584811ee-264e-444c-8157-320bf1c5d570
Catalogue record
Date deposited: 05 Jul 2022 00:19
Last modified: 16 Mar 2024 19:55
Export record
Contributors
Author:
James Merrington
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics