An investigation into the role of matrix metalloproteinases in liver metastases from colorectal cancer
An investigation into the role of matrix metalloproteinases in liver metastases from colorectal cancer
A review of the literature of the natural history, treatment and survival of patients with colorectal cancer and liver metastases from colorectal cancer has been undertaken. Special reference has been made to the metastatic process and the role of various clinicopathological and biological markers in determining outcome. A critique of the role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in cancer and metastasis is made and a potential role in liver metastases from colorectal cancer discussed.
Immunohistochemistry has been used to investigate the expression of matrix metalloproteinases -1, -7 & -9 and tissue inhibitors of matrix metalloproteinases -1 & -2 in archival tissue from 105 patients who underwent hepatic resection for colorectal cancer metastases. The expression of the matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases were analysed both for a descriptive picture and with respect to patient outcome.
Variability in expression levels of these enzymes is demonstrated and the correlation with patient outcome is explored. In addition the clinicopathological variables for each patient are also examined for prognostic significance.
The description of matrix metalloproteinases -1, -7 & -9 and tissue inhibitors of matrix metalloproteinases -1 & -2 in colorectal liver metastases is novel. The hypothesis that these enzymes have prognostic significance in colorectal liver metastases is partially supported and the need for further research is emphasised.
University of Southampton
Howell, Robert Duncan
c8fa2d4d-0100-41f9-a126-91c87074bb40
2002
Howell, Robert Duncan
c8fa2d4d-0100-41f9-a126-91c87074bb40
Howell, Robert Duncan
(2002)
An investigation into the role of matrix metalloproteinases in liver metastases from colorectal cancer.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
A review of the literature of the natural history, treatment and survival of patients with colorectal cancer and liver metastases from colorectal cancer has been undertaken. Special reference has been made to the metastatic process and the role of various clinicopathological and biological markers in determining outcome. A critique of the role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in cancer and metastasis is made and a potential role in liver metastases from colorectal cancer discussed.
Immunohistochemistry has been used to investigate the expression of matrix metalloproteinases -1, -7 & -9 and tissue inhibitors of matrix metalloproteinases -1 & -2 in archival tissue from 105 patients who underwent hepatic resection for colorectal cancer metastases. The expression of the matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases were analysed both for a descriptive picture and with respect to patient outcome.
Variability in expression levels of these enzymes is demonstrated and the correlation with patient outcome is explored. In addition the clinicopathological variables for each patient are also examined for prognostic significance.
The description of matrix metalloproteinases -1, -7 & -9 and tissue inhibitors of matrix metalloproteinases -1 & -2 in colorectal liver metastases is novel. The hypothesis that these enzymes have prognostic significance in colorectal liver metastases is partially supported and the need for further research is emphasised.
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Published date: 2002
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Local EPrints ID: 465070
URI: http://eprints.soton.ac.uk/id/eprint/465070
PURE UUID: 442f07e2-6875-4329-8ca2-e6cd1d46b31e
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Date deposited: 05 Jul 2022 00:21
Last modified: 16 Mar 2024 19:56
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Author:
Robert Duncan Howell
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