Eantioselective receptors for racemate separation of amino acids' derivatives

Abstract

This thesis entails the synthesis of a series of thiourea-based macrocyclic receptors and their ability to selectively bind amino acid derivatives.  Efforts focused on the synthesis of receptors specifically designed to bind to glutamate.

Chapter two discusses the synthesis of a bisthiourea-based macrocyclic receptor and its ability to selectivity bind to N-Boc protected glutamate.  Other derivatives were considered, such as aspartate, to fully investigate its binding properties.  Traditional NMR titration studies and isothermal calorimetry were employed as tools to study the complexation process in different solvents.  Synthetic variations were prepared, which are discussed in chapter three.  (Fig. 10777)

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