Base-free anaerobic Cu(II) catalysed aryl-nitrogen bond formations
Base-free anaerobic Cu(II) catalysed aryl-nitrogen bond formations
Graphical abstract
The Cu(II) catalysed coupling of arylboronic acids with imidazole can be performed at ambient temperature without the need for base or dioxygen. The presence of water however is essential for the reaction to proceed.
Abstract
The coupling of arylboronic acids with imidazole in the presence of binuclear bis-l-hydroxy copper(II) complexes is reported. The reactions can be performed in air as well as under nitrogen atmosphere. Reactions are carried out at ambient temperature without the need for base. The presence of water is essential for the reaction to proceed. Ligand effects on the yield and selectivity are reported.
C–N coupling, catalysts, Cu(II) complexes, solvent effects, ligand design.
7659-7662
van Berkel, Sander S.
bf9cfb58-0006-45b6-b4e8-5843f5cd507f
van den Hoogenband, Adri
43618888-2931-4685-b1cb-7d78374ecc59
Terpstra, Jan Willem
953c1cec-9fac-49ce-b916-6c37ca997a26
Tromp, Moniek
48c1ebbb-579c-42b6-83bb-7188c668b322
van Leeuwen, Piet W.N.M.
72be186e-52c4-47fc-a129-ddc1a8294fa4
van Strijdonck, Gino P.F.
ab1a4dc5-7547-42e7-b440-38ea02d463d3
4 October 2004
van Berkel, Sander S.
bf9cfb58-0006-45b6-b4e8-5843f5cd507f
van den Hoogenband, Adri
43618888-2931-4685-b1cb-7d78374ecc59
Terpstra, Jan Willem
953c1cec-9fac-49ce-b916-6c37ca997a26
Tromp, Moniek
48c1ebbb-579c-42b6-83bb-7188c668b322
van Leeuwen, Piet W.N.M.
72be186e-52c4-47fc-a129-ddc1a8294fa4
van Strijdonck, Gino P.F.
ab1a4dc5-7547-42e7-b440-38ea02d463d3
van Berkel, Sander S., van den Hoogenband, Adri, Terpstra, Jan Willem, Tromp, Moniek, van Leeuwen, Piet W.N.M. and van Strijdonck, Gino P.F.
(2004)
Base-free anaerobic Cu(II) catalysed aryl-nitrogen bond formations.
Tetrahedron Letters, 45 (41), .
(doi:10.1016/j.tetlet.2004.08.094).
Abstract
Graphical abstract
The Cu(II) catalysed coupling of arylboronic acids with imidazole can be performed at ambient temperature without the need for base or dioxygen. The presence of water however is essential for the reaction to proceed.
Abstract
The coupling of arylboronic acids with imidazole in the presence of binuclear bis-l-hydroxy copper(II) complexes is reported. The reactions can be performed in air as well as under nitrogen atmosphere. Reactions are carried out at ambient temperature without the need for base. The presence of water is essential for the reaction to proceed. Ligand effects on the yield and selectivity are reported.
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More information
Published date: 4 October 2004
Keywords:
C–N coupling, catalysts, Cu(II) complexes, solvent effects, ligand design.
Identifiers
Local EPrints ID: 46517
URI: http://eprints.soton.ac.uk/id/eprint/46517
ISSN: 0040-4039
PURE UUID: bc7d8528-1d59-4da7-8aaf-533804ce2058
Catalogue record
Date deposited: 04 Jul 2007
Last modified: 15 Mar 2024 09:24
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Contributors
Author:
Sander S. van Berkel
Author:
Adri van den Hoogenband
Author:
Jan Willem Terpstra
Author:
Moniek Tromp
Author:
Piet W.N.M. van Leeuwen
Author:
Gino P.F. van Strijdonck
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