Development of enantioselective receptors for separations of racemic mixtures of carboxylic acid derivatives

Douhéret, David (2004) Development of enantioselective receptors for separations of racemic mixtures of carboxylic acid derivatives. University of Southampton, Doctoral Thesis.

Record type: Thesis (Doctoral)

Abstract

This thesis is concerned with the synthesis and subsequent investigation of the properties of thiourea based receptors for carboxylic acid derivatives. Chapter two describes the synthesis of different phenyl and pyridyl thioureas as Carboxylic Binding Sites (59-61, 65-67) for U-shape receptors. Binding studies indicate the suitability of these thioureas for further work on the development of the receptors. Attention is also given to the level of conformational control (preorganisation) present in the receptor. ARM X , - X ^ - C H ,N Y-S,NH^+ (Y = = X2 = CH) 59 (Y = S,)Q = CH,X2=N)60 (Y = S,)Q = X2 = N)61 (Y = NH2\ Xi = X2 = CH) 65 (Y = NH2^ XI = CH,X2 = N)66 (Y = NH2^ XI = X 2 = N ) 67

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