Lewis acid mediated cyclisations of methylenecyclopropyl imines
Lewis acid mediated cyclisations of methylenecyclopropyl imines
Chapter 1 contains background information on synthetic chemistry involving methylenecyclopropanes. Background information on allylsilane chemistry involving Lewis acids is also described.
Chapter 2 describes synthesis and cyclisation studies of simple methylenecyclopropyl imines with different Lewis acids. These imines were found to be too unreactive for cyclisation to occur.
Chapter 3 describes the synthesis and cyclisation studies of methylenecyclopropyl imines with silyl substitution on the methylenecyclopropyl ring. Imines derived from methylenecyclopropane butyl amine were found to have the chain length required for cyclisation reactions. Various different Lewis acids and reaction conditions were studied for optimisation of the cyclisation reaction.
Chapter 4 discusses the synthesis and cyclisation studies of silylated methylenecyclopropyl imines derived from methylenecyclopropyl butyl amines with substitution on the linking alkyl chain. Effect of substitution patterns on the cyclisation reaction was studied, and was found to have an effect on the cyclisation reaction.
University of Southampton
Rajamäki, Suvi Henna Maria
0a45be7c-039f-4215-b4ff-d6cc2c2676c4
2004
Rajamäki, Suvi Henna Maria
0a45be7c-039f-4215-b4ff-d6cc2c2676c4
Rajamäki, Suvi Henna Maria
(2004)
Lewis acid mediated cyclisations of methylenecyclopropyl imines.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
Chapter 1 contains background information on synthetic chemistry involving methylenecyclopropanes. Background information on allylsilane chemistry involving Lewis acids is also described.
Chapter 2 describes synthesis and cyclisation studies of simple methylenecyclopropyl imines with different Lewis acids. These imines were found to be too unreactive for cyclisation to occur.
Chapter 3 describes the synthesis and cyclisation studies of methylenecyclopropyl imines with silyl substitution on the methylenecyclopropyl ring. Imines derived from methylenecyclopropane butyl amine were found to have the chain length required for cyclisation reactions. Various different Lewis acids and reaction conditions were studied for optimisation of the cyclisation reaction.
Chapter 4 discusses the synthesis and cyclisation studies of silylated methylenecyclopropyl imines derived from methylenecyclopropyl butyl amines with substitution on the linking alkyl chain. Effect of substitution patterns on the cyclisation reaction was studied, and was found to have an effect on the cyclisation reaction.
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Published date: 2004
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Local EPrints ID: 465291
URI: http://eprints.soton.ac.uk/id/eprint/465291
PURE UUID: 5bf9fb6b-23f4-4220-9e53-64b3590a2e46
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Date deposited: 05 Jul 2022 00:35
Last modified: 16 Mar 2024 20:05
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Author:
Suvi Henna Maria Rajamäki
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