Clinicopathological studies of malignant pleural mesothelioma
Clinicopathological studies of malignant pleural mesothelioma
The UK is currently in the midst of a mesothelioma epidemic: The incidence of malignant pleural mesothelioma (MPM) has risen more than 10-fold in the last 40 years, and is predicted to continue rising for at least another decade. Despite this increase, there are many aspects of the aetiology, epidemiology and pathology of MPM that are not fully understood.
In this thesis I have summarised what is known of the causes of malignant change in the pleura, including mechanisms by which asbestos induces mesothelioma. I have also examined the evidence implicating radiation and simian virus 40 as causes of MPM.
Mesothelioma can exhibit many different patterns of differentiation, making it difficult to distinguish from other processes affecting the pleura. I have described the difficulties associated with confirming the diagnosis of MPM, detailed the different diagnostic modalities used to diagnose MPM, and performed a meta-analysis of published papers that have assessed the value of diagnostic immunohistochemistry in this area.
The relationship between patient factors and prognosis is also not clearly understood. I have analysed a cohort of 553 patients with MPM in terms of their presenting features, pathology and survival, in order to identify factors that may be of prognostic value.
Finally, recent advances in molecular biology have shed light on the mechanisms that control normal and malignant cells. The cytokine transforming growth factor-β1 (TGF-β1) critically influences the extra-cellular matrix, and is implicated in the development of tissue fibrosis, malignant invasion and metastasis. I have investigated the influence that TGF-β1 DNA polymorphisms may have on lung fibrosis, and on histological subtype and patient survival in MPM.
University of Southampton
King, Juliet Elizabeth
c46a8b93-d304-48bc-96c0-062bee6daf57
2004
King, Juliet Elizabeth
c46a8b93-d304-48bc-96c0-062bee6daf57
King, Juliet Elizabeth
(2004)
Clinicopathological studies of malignant pleural mesothelioma.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The UK is currently in the midst of a mesothelioma epidemic: The incidence of malignant pleural mesothelioma (MPM) has risen more than 10-fold in the last 40 years, and is predicted to continue rising for at least another decade. Despite this increase, there are many aspects of the aetiology, epidemiology and pathology of MPM that are not fully understood.
In this thesis I have summarised what is known of the causes of malignant change in the pleura, including mechanisms by which asbestos induces mesothelioma. I have also examined the evidence implicating radiation and simian virus 40 as causes of MPM.
Mesothelioma can exhibit many different patterns of differentiation, making it difficult to distinguish from other processes affecting the pleura. I have described the difficulties associated with confirming the diagnosis of MPM, detailed the different diagnostic modalities used to diagnose MPM, and performed a meta-analysis of published papers that have assessed the value of diagnostic immunohistochemistry in this area.
The relationship between patient factors and prognosis is also not clearly understood. I have analysed a cohort of 553 patients with MPM in terms of their presenting features, pathology and survival, in order to identify factors that may be of prognostic value.
Finally, recent advances in molecular biology have shed light on the mechanisms that control normal and malignant cells. The cytokine transforming growth factor-β1 (TGF-β1) critically influences the extra-cellular matrix, and is implicated in the development of tissue fibrosis, malignant invasion and metastasis. I have investigated the influence that TGF-β1 DNA polymorphisms may have on lung fibrosis, and on histological subtype and patient survival in MPM.
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Published date: 2004
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Local EPrints ID: 465619
URI: http://eprints.soton.ac.uk/id/eprint/465619
PURE UUID: 7ba024e1-eb46-4cdf-9d71-0e42cf3ed536
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Date deposited: 05 Jul 2022 02:06
Last modified: 16 Mar 2024 20:17
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Author:
Juliet Elizabeth King
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